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Nutrients 2017, 9(8), 829; doi:10.3390/nu9080829

Evaluation of Blood Biomarkers Associated with Risk of Malnutrition in Older Adults: A Systematic Review and Meta-Analysis

1
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA
2
Abbott Nutrition Research and Development Asia-Pacific Center, 138668 Singapore, Singapore
3
Abbott Nutrition Research and Development, Columbus, OH 43219, USA
4
Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29412, USA
*
Author to whom correspondence should be addressed.
Received: 3 July 2017 / Revised: 22 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
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Abstract

Malnutrition is a common yet under-recognized problem in hospitalized patients. The aim of this paper was to systematically review and evaluate malnutrition biomarkers among order adults. Eligible studies were identified through Cochrane, PubMed and the ProQuest Dialog. A meta-regression was performed on concentrations of biomarkers according to malnutrition risks classified by validated nutrition assessment tools. A total of 111 studies were included, representing 52,911 participants (55% female, 72 ± 17 years old) from various clinical settings (hospital, community, care homes). The estimated BMI (p < 0.001) and concentrations of albumin (p < 0.001), hemoglobin (p < 0.001), total cholesterol (p < 0.001), prealbumin (p < 0.001) and total protein (p < 0.05) among subjects at high malnutrition risk by MNA were significantly lower than those without a risk. Similar results were observed for malnutrition identified by SGA and NRS-2002. A sensitivity analysis by including patients with acute illness showed that albumin and prealbumin concentrations were dramatically reduced, indicating that they must be carefully interpreted in acute care settings. This review showed that BMI, hemoglobin, and total cholesterol are useful biomarkers of malnutrition in older adults. The reference ranges and cut-offs may need to be updated to avoid underdiagnosis of malnutrition. View Full-Text
Keywords: malnutrition; biomarker; nutrition screening tools; BMI; albumin; prealbumin; hospitalized patients malnutrition; biomarker; nutrition screening tools; BMI; albumin; prealbumin; hospitalized patients
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MDPI and ACS Style

Zhang, Z.; Pereira, S.L.; Luo, M.; Matheson, E.M. Evaluation of Blood Biomarkers Associated with Risk of Malnutrition in Older Adults: A Systematic Review and Meta-Analysis. Nutrients 2017, 9, 829.

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