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Nutrients 2017, 9(7), 747; doi:10.3390/nu9070747

Dietary Supplementation of Fermented Rice Bran Effectively Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice

1
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai 980-0845, Japan
2
International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai 980-0845, Japan
3
Faculty of Agriculture, Yamagata University, Tsuruoka 997-8555, Japan
4
Cellular Biology Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 980-0845, Japan
5
Department of Food Technology, Universitas Bakrie, Jakarta 12920, Indonesia
6
Faculty of Agricultural Engineering and Technology, Bogor Agricultural University, Bogor 16680, Indonesia
*
Authors to whom correspondence should be addressed.
Received: 29 May 2017 / Revised: 2 July 2017 / Accepted: 10 July 2017 / Published: 13 July 2017
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Abstract

Rice bran (RB) is a major by-product of rice polishing and a rich source of bioactive compounds. Here, we investigated the anti-colitis effect of diet supplementation with fermented rice bran (FRB) in a murine model of ulcerative colitis. FRB was prepared by dual fermentation of RB using fungi and lactic acid bacteria. Colitis was induced in C57Bl/6N male mice (n = 8/group) by dextran sodium sulfate (DSS). Body weight change, disease activity index (DAI), histopathology score, tissue myeloperoxidase (MPO) activity, cytokine and chemokine transcript levels, and the production of short-chain fatty acids (SCFAs) and mucin in the colonic tissue were monitored. Based on histopathology scores, DSS induced severe mucosal inflammation, with an increased loss of crypts, and inflammatory cell infiltration in the control and RB groups, but not in the FRB group. MPO activity, thiobarbituric acid-reactive substance levels, and pro-inflammatory cytokine transcript (Tnf-α, Il-1β, Il-6, and Il-17) levels were significantly higher in the control and RB groups than in the FRB group. Thus, dietary FRB attenuated intestinal inflammation owing to elevated SCFAs and tryptamine production, which might regulate tight junction barrier integrity and intestinal homeostasis. These results suggest that FRB could comprise an effective potential preventive agent for ulcerative colitis. View Full-Text
Keywords: fermented rice bran; short chain fatty acids; tryptophan; tryptamine fermented rice bran; short chain fatty acids; tryptophan; tryptamine
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Islam, J.; Koseki, T.; Watanabe, K.; Ardiansyah; Budijanto, S.; Oikawa, A.; Alauddin, M.; Goto, T.; Aso, H.; Komai, M.; Shirakawa, H. Dietary Supplementation of Fermented Rice Bran Effectively Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice. Nutrients 2017, 9, 747.

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