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Nutrients 2017, 9(7), 699; doi:10.3390/nu9070699

Reduction of Asthmatic Parameters by Sea Hare Hydrolysates in a Mouse Model of Allergic Asthma

1
Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea
2
Department of Physiology and Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
3
Department of Anatomy and Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
4
Sunmarin Biotech, Tongyeong 53064, Korea
5
Department of Seafood Science and Technology and Institute of Marine Industry, Gyeongsang National University, Tongyeong 53064, Korea
6
Department of Microbiology and Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 April 2017 / Revised: 30 June 2017 / Accepted: 3 July 2017 / Published: 5 July 2017
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Abstract

Sea hare has a variety of biological activities. However, little is known regarding the anti-asthmatic effects of sea hare. This study was performed to identify the effect of sea hare hydrolysates (SHH) on an ovalbumin (OVA)-induced allergic asthma model. The experimental asthma model was sensitized and challenged with OVA. We found that a high-dose of SHH (HSHH) significantly inhibited OVA-induced airway inflammation and mucus production around the airway in lung sections, while low- and medium-dose SHH showed an insignificant effect. In addition, HSHH highly reduced OVA-induced production of interleukin-4, -5, -13, leukotriene D4, E4, and histamine in bronchoalveolar lavage fluid. HSHH decreased the histamine-induced increase in the intracellular Ca2+ level and contractions in asthmatic smooth muscle cells. Furthermore, HSHH did not affect the weights of the spleen nor thymus, whereas dexamethasone (DEX), a steroidal anti-inflammatory drug, reduced them. Taken together, these results showed that HSHH reduced asthmatic parameters in a mouse model of allergic asthma, and suggest that SHH could be used as a potential therapeutic agent for asthma. View Full-Text
Keywords: airway smooth muscle cell; asthma; cytokines; sea hare hydrolysates airway smooth muscle cell; asthma; cytokines; sea hare hydrolysates
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Ryu, J.H.; Xie, C.; Kim, E.-J.; Park, S.-H.; Choi, Y.J.; Kang, S.S.; Shin, M.-K.; Kang, D. Reduction of Asthmatic Parameters by Sea Hare Hydrolysates in a Mouse Model of Allergic Asthma. Nutrients 2017, 9, 699.

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