Reduction of Asthmatic Parameters by Sea Hare Hydrolysates in a Mouse Model of Allergic Asthma
AbstractSea hare has a variety of biological activities. However, little is known regarding the anti-asthmatic effects of sea hare. This study was performed to identify the effect of sea hare hydrolysates (SHH) on an ovalbumin (OVA)-induced allergic asthma model. The experimental asthma model was sensitized and challenged with OVA. We found that a high-dose of SHH (HSHH) significantly inhibited OVA-induced airway inflammation and mucus production around the airway in lung sections, while low- and medium-dose SHH showed an insignificant effect. In addition, HSHH highly reduced OVA-induced production of interleukin-4, -5, -13, leukotriene D4, E4, and histamine in bronchoalveolar lavage fluid. HSHH decreased the histamine-induced increase in the intracellular Ca2+ level and contractions in asthmatic smooth muscle cells. Furthermore, HSHH did not affect the weights of the spleen nor thymus, whereas dexamethasone (DEX), a steroidal anti-inflammatory drug, reduced them. Taken together, these results showed that HSHH reduced asthmatic parameters in a mouse model of allergic asthma, and suggest that SHH could be used as a potential therapeutic agent for asthma. View Full-Text
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Ryu, J.H.; Xie, C.; Kim, E.-J.; Park, S.-H.; Choi, Y.J.; Kang, S.S.; Shin, M.-K.; Kang, D. Reduction of Asthmatic Parameters by Sea Hare Hydrolysates in a Mouse Model of Allergic Asthma. Nutrients 2017, 9, 699.
Ryu JH, Xie C, Kim E-J, Park S-H, Choi YJ, Kang SS, Shin M-K, Kang D. Reduction of Asthmatic Parameters by Sea Hare Hydrolysates in a Mouse Model of Allergic Asthma. Nutrients. 2017; 9(7):699.Chicago/Turabian Style
Ryu, Ji H.; Xie, Chengliang; Kim, Eun-Jin; Park, Si-Hyang; Choi, Yeung J.; Kang, Sang S.; Shin, Min-Kyoung; Kang, Dawon. 2017. "Reduction of Asthmatic Parameters by Sea Hare Hydrolysates in a Mouse Model of Allergic Asthma." Nutrients 9, no. 7: 699.
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