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Nutrients 2017, 9(7), 689; doi:10.3390/nu9070689

Anti-Obesity Effect of the Above-Ground Part of Valeriana dageletiana Nakai ex F. Maek Extract in High-Fat Diet-Induced Obese C57BL/6N Mice

1,2,†
,
2,†
,
3,†
and
2,3,4,*
1
Department of Preventive Medicine and Health Management, Hebei University, Baoding 071002, China
2
Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea
3
Institute of Natural Medicine, Hallym University, Chuncheon 24252, Korea
4
Institute of Korean Nutrition, Hallym University, Chuncheon 24252, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 11 May 2017 / Revised: 16 June 2017 / Accepted: 18 June 2017 / Published: 2 July 2017
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Abstract

Valeriana dageletiana Nakai ex F. Maek (VD) has been used as traditional medicine for the treatment of restlessness and sleeping disorders. However, it is still unclear whether obesity in mice can be altered by diet supplementation with VD. In this study, we first investigated the influences of VD on the accumulation of lipid content in 3T3-L1 cells; and the results showed that the above-ground VD extracts (VDAE) suppressed the differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner without cytotoxicity. Thus, the effects of VDAE on preventing obesity were then studied in the C57BL/6N mice for 10 weeks (n = 6): normal-fat diet, high-fat diet (HFD), HFD supplemented with 1% (10 g/kg) Garcinia combogia extract (positive control), and HFD supplemented with 1% (10 g/kg) VDAE. The results showed that VDAE reduced food efficiency ratio, body weight, epididymal adipose and hepatic tissue weight, hepatic lipid metabolites, and triacylglycerol and cholesterol serum levels compared to the high-fat diet group. Moreover, VD significantly inhibited the expression of adipogenic genes, such as PPAR-γ, C/EBP-α, and aP2, and lipogenic genes, such as SREBP-1c, FAS, SCD-1, and CD36, in epididymal adipose tissue and hepatic tissue. These findings indicate anti-adipogenic and anti-lipogenic effects of VDAE and suggest that it could be a potent functional food ingredient for the prevention of high-fat diet-induced obesity. View Full-Text
Keywords: 3T3-L1; herbal medicine; epididymal adipose tissue; fatty liver; adipogenesis; lipogenesis; lipid profile 3T3-L1; herbal medicine; epididymal adipose tissue; fatty liver; adipogenesis; lipogenesis; lipid profile
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Wang, Z.; Hwang, S.H.; Kim, J.H.; Lim, S.S. Anti-Obesity Effect of the Above-Ground Part of Valeriana dageletiana Nakai ex F. Maek Extract in High-Fat Diet-Induced Obese C57BL/6N Mice. Nutrients 2017, 9, 689.

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