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Nutrients 2017, 9(6), 636; doi:10.3390/nu9060636

Lack of Association between Serum Vitamin B6, Vitamin B12, and Vitamin D Levels with Different Types of Glaucoma: A Systematic Review and Meta-Analysis

1,†
,
2,†
,
1
,
1,3,* and 3,4,5,6,*
1
Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China
2
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School, Xi’an Jiaotong University, Xi’an 710061, China
3
Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China
4
State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200031, China
5
Key Laboratory of Myopia, Ministry of Health, Fudan University, Shanghai 200031, China
6
Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 15 April 2017 / Revised: 13 June 2017 / Accepted: 15 June 2017 / Published: 21 June 2017
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Abstract

Although vitamins play a major role in health, and their deficiency may be linked to symptoms of optic-nerve dysfunction, the association between serum vitamin levels and glaucoma in humans remains controversial. In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 25March 2017. Nine studies on primary open-angle glaucoma (POAG), four studies on normal tension glaucoma (NTG), and six studies on exfoliative glaucoma (EXG) were retrieved. The combined results showed no differences in the levels of serum vitamin B6 between POAG (p = 0.406) and EXG (p = 0.139) patients and controls. The weighted mean differences (WMDs) with 95% confidence intervals (CIs) were 2.792 ng/mL (−3.793 to 9.377) and 1.342 ng/mL (−3.120 to 0.436), respectively. There was no difference between POAG (p = 0.952), NTG (p = 0.757), or EXG (p = 0.064) patients and controls in terms of serum vitamin B12. The WMDs with 95% CIs were 0.933 pg/mL (−31.116 to 29.249), 6.652 pg/mL (−35.473 to 48.777), and 49.946 pg/mL (−102.892 to 3.001), respectively. The serum vitamin D levels exhibited no differences (p = 0.064) between POAG patients and controls; the WMD with 95% CI was 2.488 ng/mL (−5.120 to 0.145). In conclusion, there was no association found between serum vitamin B6, vitamin B12, or vitamin D levels and the different types of glaucoma. View Full-Text
Keywords: glaucoma; vitamin B6; vitamin B12; vitamin D; meta-analysis glaucoma; vitamin B6; vitamin B12; vitamin D; meta-analysis
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Li, S.; Li, D.; Shao, M.; Cao, W.; Sun, X. Lack of Association between Serum Vitamin B6, Vitamin B12, and Vitamin D Levels with Different Types of Glaucoma: A Systematic Review and Meta-Analysis. Nutrients 2017, 9, 636.

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