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Nutrients 2017, 9(6), 625; doi:10.3390/nu9060625

Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies

1
Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori—IRCCS–“Fondazione G. Pascale”, Via Mariano Semmola, 80131 Naples, Italy
2
S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori—IRCCS—“Fondazione G. Pascale”, 80131 Naples, Italy
3
Clinical, Experimental and Medical Sciences, Chair of Nephrology, Department of Cardio-Vascular Medicine, University of Study of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
4
Division of Infantile Neuropsychiatry, UOMI-Maternal and Infant Health, Asl NA 3 SUD, Torre del Greco, Via Marconi, 80059 Naples, Italy
These authors have contributed equally.
These authors are co-last authors.
*
Author to whom correspondence should be addressed.
Received: 12 May 2017 / Revised: 14 June 2017 / Accepted: 15 June 2017 / Published: 17 June 2017
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Abstract

Background: Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity. AIM: To analyze and report the outcome of experimental animal studies on the protective effects of NS/TQ on chemotherapy-associated kidney complications. Design: Standard systematic review and narrative synthesis. Data Sources: MEDLINE, EMBASE databases were searched for relevant articles published up to March 2017. Additionally, a manual search was performed. Criteria for a study’s inclusion were: conducted in animals, systematic reviews and meta-analysis, containing data on nephroprotective effects of NS/TQ compared to a placebo or other substance. All strains and genders were included. Results: The database search yielded 71 studies, of which 12 (cisplatin-induced nephrotoxicity 8; methotrexate-induced nephrotoxicity 1; doxorubicin-induced nephrotoxicity 2; ifosfamide-induced nephrotoxicity 1) were included in this review. Conclusions: Experimental animal studies showed the protective effect of NS, or TQ, on chemotherapy-induced nephrotoxicity. These effects are caused by decreasing lipid peroxidation and increasing activity of antioxidant enzymes in renal tissue of chemotherapy-treated animals. View Full-Text
Keywords: Nigella sativa; Thymoquinone; natural compounds; chemotherapy-induced nephrotoxicity Nigella sativa; Thymoquinone; natural compounds; chemotherapy-induced nephrotoxicity
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Cascella, M.; Palma, G.; Barbieri, A.; Bimonte, S.; Amruthraj, N.J.; Muzio, M.R.; del Vecchio, V.; Rea, D.; Falco, M.; Luciano, A.; Arra, C.; Cuomo, A. Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies. Nutrients 2017, 9, 625.

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