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Nutrients 2017, 9(6), 623; doi:10.3390/nu9060623

Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial

1
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria
2
Swiss Cardiovascular Center Bern, Department of Cardiology, Bern University Hospital, 3010 Bern, Switzerland
3
Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria
4
Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, 32545 Bad Oeynhausen, Germany
5
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
6
Department of Internal Medicine, Division of Nephrology, Medical University of Graz, 8036 Graz, Austria
7
Bad Gleichenberg Clinic, 8344 Bad Gleichenberg, Austria
8
Medical Clinic V (Nephrology, Hypertensiology, Endocrinology), Medical Faculty Mannheim, Ruperto Carola University Heidelberg, 68167 Mannheim, Germany
9
CBmed, Center for Biomarker Research in Medicine, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Received: 27 April 2017 / Revised: 12 June 2017 / Accepted: 13 June 2017 / Published: 17 June 2017
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Abstract

Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH)2D) concentrations (secondary outcome). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial—a single-center, double-blind, randomized, placebo-controlled trial (RCT) conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two-hundred subjects with arterial hypertension and 25(OH)D concentrations <30 ng/mL were randomized to either receive 2800 IU of vitamin D daily or placebo for eight weeks. A total of 175 participants (mean ± standard deviation age, 60 ± 11 years; 49% women) with available IGF-1 concentrations were included in the present analysis. At baseline, IGF-1 concentrations were significantly correlated with 1,25(OH)2D (r = 0.21; p = 0.005) but not with 25(OH)D (r = −0.008; p = 0.91). In the RCT, vitamin D had no significant effect on IGF-1 (mean treatment effect 3.1; 95% confidence interval −5.6 to 11.9 ng/mL; p = 0.48), but it increased 1,25(OH)2D concentrations (mean treatment effect 9.2; 95% confidence interval 4.4 to 13.9 pg/mL; p ≤ 0.001). In this RCT, in hypertensive patients with low 25(OH)D concentrations, there was no significant effect of vitamin D supplementation on IGF-1 concentrations. However, we observed a cross-sectional correlation between 1,25(OH)2D and IGF-1 and an increase of 1,25(OH)2D after vitamin D supplementation. View Full-Text
Keywords: insulin-like growth factor-1; calcitriol; vitamin D supplementation insulin-like growth factor-1; calcitriol; vitamin D supplementation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Trummer, C.; Schwetz, V.; Pandis, M.; Grübler, M.R.; Verheyen, N.; Gaksch, M.; Zittermann, A.; März, W.; Aberer, F.; Lang, A.; Friedl, C.; Tomaschitz, A.; Obermayer-Pietsch, B.; Pieber, T.R.; Pilz, S.; Treiber, G. Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial. Nutrients 2017, 9, 623.

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