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Nutrients 2017, 9(6), 619; doi:10.3390/nu9060619

A High-Fructose-High-Coconut Oil Diet Induces Dysregulating Expressions of Hippocampal Leptin and Stearoyl-CoA Desaturase, and Spatial Memory Deficits in Rats

1
Department of Nutrition and Health Sciences, Kainan University, No. 1, Kainan Rd., Luchu, Taoyuan 338, Taiwan
2
School of Nutrition and Health Sciences, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan
3
Research Center of Geriatric Nutrition, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan
*
Author to whom correspondence should be addressed.
Received: 8 May 2017 / Revised: 7 June 2017 / Accepted: 14 June 2017 / Published: 16 June 2017
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Abstract

We investigated the effects of high-fructose-high-fat diets with different fat compositions on metabolic parameters, hippocampal-dependent cognitive function, and brain leptin (as well as stearoyl-CoA desaturase (SCD1) mRNA expressions). Thirty-two male Wistar rats were divided into 3 groups, a control group (n = 8), a high-fructose soybean oil group (37.5% of fat calories, n = 12), and a high-fructose coconut oil group (37.5% of fat calories, n = 12) for 20 weeks. By the end of the study, the coconut oil group exhibited significantly higher serum fasting glucose, fructosamine, insulin, leptin, and triglyceride levels compared to those of the control and soybean oil groups. However, hippocampal leptin expression and leptin receptor mRNA levels were significantly lower, while SCD1 mRNA was significantly higher in rats fed the high-fructose-high-coconut oil diet than in rats fed the other experimental diets. In addition, the coconut oil group spent significantly less time in the target quadrant on the probe test in the Morris water maze (MWM) task. Rats fed the high-fructose-high-coconut oil diet for 20 weeks were prone to develop hyperglycemia, hyperinsulinemia, hyperleptinemia, and hypertriglyceridemia. These metabolic consequences may contribute to hippocampal-dependent memory impairment, accompanied by a lower central leptin level, and a higher SCD1 gene expression in the brain. View Full-Text
Keywords: fructose; fat; leptin; stearoyl-CoA desaturase; coconut; soybean fructose; fat; leptin; stearoyl-CoA desaturase; coconut; soybean
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Lin, C.-I.; Shen, C.-F.; Hsu, T.-H.; Lin, S.-H. A High-Fructose-High-Coconut Oil Diet Induces Dysregulating Expressions of Hippocampal Leptin and Stearoyl-CoA Desaturase, and Spatial Memory Deficits in Rats. Nutrients 2017, 9, 619.

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