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Nutrients 2017, 9(5), 459; doi:10.3390/nu9050459

Acute Vitamin D3 Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin

1
Laboratory of Metabolic Research, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, 28921 Piancavallo-Verbania, Italy
2
Laboratory of Paediatrics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy
3
Laboratory of Clinical Neurobiology, I.R.C.C.S. Istituto Auxologico Italiano, Ospedale S. Giuseppe, 28921 Piancavallo-Verbania, Italy
4
Division of General Medicine, I.R.C.C.S. Istituto Auxologico Italiano, Ospedale S. Giuseppe, 28921 Piancavallo-Verbania, Italy
5
Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy
6
Department of Neuroscience, Università di Torino, 10124 Torino, Italy
7
Department of Clinical Sciences and Community Health, Università di Milano, 20122 Milano, Italy
*
Author to whom correspondence should be addressed.
Received: 14 March 2017 / Revised: 27 April 2017 / Accepted: 29 April 2017 / Published: 5 May 2017
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Abstract

Obesity predisposes to vitamin D deficiency (VDD) and glucose abnormalities. It is currently debated if vitamin D administration may improve glucose homeostasis by interacting with modulators of insulin sensitivity, such as adiponectin and its oligomers. In a 4-week inpatient study on a metabolic rehabilitation program, consisting of individualized caloric restriction and aerobic physical exercise in obese subjects with VDD, we assessed the acute effects of 600,000 IU cholecalciferol given per os VD group, 12 subjects; body mass index (BMI) 42.7 ± 1.3 kg/m2) or placebo per os (PL group, 12 subjects, BMI 39.8 ± 0.9 kg/m2) on high (HWM-A), medium (MMW-A), and low molecular weight adiponectin (LMW-A), as quantified by western immunoblot (WIB) and ELISA. During the 4-week study, dieting promoted a similar magnitude of weight loss in VD and PL groups. Compared to the PL group, cholecalciferol administration increased 25(OH)Vit D levels (p < 0.001) and promoted a significant increase of HMW-A expression analyzed by WIB (p = 0.02). In parallel, a significant decrease of leptin/HMW-A ratio (p < 0.05), a biomarker of metabolic homeostasis, was observed. During the study, changes of MMW-A and LMW-A occurred independently of cholecalciferol administration, and were likely explained by weight loss. At odds with these findings, the ELISA assessment of adiponectin oligomers showed no modifications in the VD group or PL group. Current findings suggest that acute cholecalciferol administration selectively modifies HMW-A and the leptin/HMW-A ratio. View Full-Text
Keywords: multimeric adiponectin; vitamin D; obesity; weight loss multimeric adiponectin; vitamin D; obesity; weight loss
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MDPI and ACS Style

Mai, S.; Walker, G.E.; Vietti, R.; Cattaldo, S.; Mele, C.; Priano, L.; Mauro, A.; Bona, G.; Aimaretti, G.; Scacchi, M.; Marzullo, P. Acute Vitamin D3 Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin. Nutrients 2017, 9, 459.

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