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Erratum published on 26 June 2017, see Nutrients 2017, 9(7), 656.

Open AccessArticle
Nutrients 2017, 9(5), 0448; doi:10.3390/nu9050448

Association between Alcohol Consumption, Folate Intake, and Risk of Pancreatic Cancer: A Case-Control Study

Department of Public Health, North Dakota State University, Fargo, ND 58102, USA
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20850, USA
Department of Epidemiology, National Institutes of Health, Bethesda, MD 20850, USA
Author to whom correspondence should be addressed.
Received: 23 December 2016 / Revised: 11 April 2017 / Accepted: 24 April 2017 / Published: 1 May 2017
(This article belongs to the Special Issue Nutrition and Pancreatic Health)
View Full-Text   |   Download PDF [201 KB, uploaded 3 July 2017]


Pancreatic cancer is one of the most fatal common cancers affecting both men and women, representing about 3% of all new cancer cases in the United States. In this study, we aimed to investigate the association of pancreatic cancer risk with alcohol consumption as well as folate intake. We performed a case-control study of 384 patients diagnosed with pancreatic cancer from May 2004 to December 2009 and 983 primary care healthy controls in a largely white population (>96%). Our findings showed no significant association between risk of pancreatic cancer and either overall alcohol consumption or type of alcohol consumed (drinks/day). Our study showed dietary folate intake had a modest effect size, but was significantly inversely associated with pancreatic cancer (odds ratio (OR) = 0.99, p < 0.0001). The current study supports the hypothesis that pancreatic cancer risk is reduced with higher food-based folate intake. View Full-Text
Keywords: pancreatic cancer; alcohol intake; folate intake; case-control study pancreatic cancer; alcohol intake; folate intake; case-control study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yallew, W.; Bamlet, W.R.; Oberg, A.L.; Anderson, K.E.; Olson, J.E.; Sinha, R.; Petersen, G.M.; Stolzenberg-Solomon, R.Z.; Jansen, R.J. Association between Alcohol Consumption, Folate Intake, and Risk of Pancreatic Cancer: A Case-Control Study. Nutrients 2017, 9, 0448.

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