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Nutrients 2017, 9(4), 365; doi:10.3390/nu9040365

25-Hydroxyvitamin D and Peripheral Immune Mediators: Results from Two Nationwide Danish Pediatric Cohorts

1
Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730 Herlev, Denmark
2
Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Oester Farimagsgade 5, 1710 Copenhagen K, Denmark
3
Department of Congenital Disorders, Center for Neonatal Screening, Statens Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark
4
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark
*
Author to whom correspondence should be addressed.
Received: 27 January 2017 / Revised: 31 March 2017 / Accepted: 1 April 2017 / Published: 6 April 2017
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Abstract

(1) Background: We aimed to examine if 25-hydroxyvitamin D (25(OH)D) was related to the peripheral immunological and inflammatory signature both at birth, and in newly diagnosed patients with childhood type 1 diabetes (T1D) and their healthy controls; (2) Methods: The birth cohort consisted of 470 patients and 500 healthy controls. Dried blood samples were collected from the neonates in the period 1981–1999. The newly diagnosed cohort consisted of 460 patients and 453 siblings. Serum samples were collected in the period 1997–2005. A variety of peripheral immune mediators were measured and compared to total 25(OH)D levels (25(OH)D2 + 25(OH)D3). For each immune mediator, the relative change (RC) in the mean level was modeled by robust log-normal regression and correction for multiple testing was performed; (3) Results: Two associations were identified; there was a negative association between 25(OH)D (10 nmol/L increase) and leptin (RC (95% confidence interval (CI)), 0.98 (0.96; 1.00)), and a positive association between 25(OH)D (10 nmol/L increase) and the chemokine, chemokine (c-x-c motif) ligand (CXCL) 8 (RC (95% CI), 1.07 (1.01; 1.13)); (4) Conclusion: CXCL8 and leptin have significant associations with levels of 25(OH)D in the newly diagnosed cohort. These results do not indicate a strong influence of 25(OH)D on the peripheral immunological or inflammatory signature. View Full-Text
Keywords: Diabetes Mellitus, Type 1; vitamin D; Cytokines/immunology; TREM1, human; C-reactive protein; mannose-binding lectin; Infant, Newborn; Child; Adolescent Diabetes Mellitus, Type 1; vitamin D; Cytokines/immunology; TREM1, human; C-reactive protein; mannose-binding lectin; Infant, Newborn; Child; Adolescent
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MDPI and ACS Style

Thorsen, S.U.; Pipper, C.B.; Skogstrand, K.; Pociot, F.; Svensson, J. 25-Hydroxyvitamin D and Peripheral Immune Mediators: Results from Two Nationwide Danish Pediatric Cohorts. Nutrients 2017, 9, 365.

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