The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus
AbstractGestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams). In addition, the individual effects of vitamin B2 were examined. Suboptimal B2 increased body weight and fat deposition, decreased GLUT4 adipose tissue expression, and increased expression of inflammatory markers. MI supplementation reduced weight and fat deposition, and reduced expression of inflammatory markers in adipose tissue of mice on suboptimal B2. MI also significantly reduced the hyperleptinemia observed in db/+ mice, when combined with supplemented B2. MI was generally associated with adipose tissue markers of improved insulin sensitivity and glucose uptake, while the combination of vitamins B2, B6, B12, and D was associated with a reduction in adipose inflammatory marker expression. These results suggest that supplementation with MI and vitamin B2 could be beneficial for the treatment/prevention of GDM. View Full-Text
- Supplementary File 1:
DOCX-Document (DOCX, 235 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Plows, J.F.; Budin, F.; Andersson, R.A.M.; Mills, V.J.; Mace, K.; Davidge, S.T.; Vickers, M.H.; Baker, P.N.; Silva-Zolezzi, I.; Stanley, J.L. The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus. Nutrients 2017, 9, 141.
Plows JF, Budin F, Andersson RAM, Mills VJ, Mace K, Davidge ST, Vickers MH, Baker PN, Silva-Zolezzi I, Stanley JL. The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus. Nutrients. 2017; 9(2):141.Chicago/Turabian Style
Plows, Jasmine F.; Budin, Florence; Andersson, Rebecka A.M.; Mills, Valerie J.; Mace, Katherine; Davidge, Sandra T.; Vickers, Mark H.; Baker, Philip N.; Silva-Zolezzi, Irma; Stanley, Joanna L. 2017. "The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus." Nutrients 9, no. 2: 141.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.