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Nutrients 2017, 9(2), 141; doi:10.3390/nu9020141

The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus

1
Liggins Institute, University of Auckland, Auckland 1021, New Zealand
2
Nestle Research Center, Lausanne 1000, Switzerland
3
University of Alberta, Edmonton, AB T6G 2R3, Canada
4
College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH, UK
*
Author to whom correspondence should be addressed.
Received: 3 November 2016 / Revised: 2 February 2017 / Accepted: 9 February 2017 / Published: 15 February 2017
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Abstract

Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams). In addition, the individual effects of vitamin B2 were examined. Suboptimal B2 increased body weight and fat deposition, decreased GLUT4 adipose tissue expression, and increased expression of inflammatory markers. MI supplementation reduced weight and fat deposition, and reduced expression of inflammatory markers in adipose tissue of mice on suboptimal B2. MI also significantly reduced the hyperleptinemia observed in db/+ mice, when combined with supplemented B2. MI was generally associated with adipose tissue markers of improved insulin sensitivity and glucose uptake, while the combination of vitamins B2, B6, B12, and D was associated with a reduction in adipose inflammatory marker expression. These results suggest that supplementation with MI and vitamin B2 could be beneficial for the treatment/prevention of GDM. View Full-Text
Keywords: gestational diabetes; myo-inositol; B2; B6; B12; D; Riboflavin; db/+; db/db; mice; LepR gestational diabetes; myo-inositol; B2; B6; B12; D; Riboflavin; db/+; db/db; mice; LepR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Plows, J.F.; Budin, F.; Andersson, R.A.M.; Mills, V.J.; Mace, K.; Davidge, S.T.; Vickers, M.H.; Baker, P.N.; Silva-Zolezzi, I.; Stanley, J.L. The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus. Nutrients 2017, 9, 141.

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