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Nutrients 2017, 9(2), 110; doi:10.3390/nu9020110

Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers

1
Turku PET Centre, University of Turku, Turku FI-20521, Finland
2
Division of Natural Sciences, Department of Health Sciences, Franklin Pierce University, Rindge, NH 03461, USA
3
Institute of Clinical Physiology, National Research Council, Pisa 56124, Italy
4
Folkhälsan Research Centre, Helsinki FI-00250, Finland
5
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki FI-00271, Finland
6
Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki FI-00014, Finland
7
Vaasa Central Hospital, Vaasa FI-65130, Finland
8
Department of Endocrinology, Turku University Hospital, Turku FI-20521, Finland
*
Author to whom correspondence should be addressed.
Received: 27 November 2016 / Revised: 10 January 2017 / Accepted: 20 January 2017 / Published: 4 February 2017
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Abstract

Background: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated with this decreased tissue-specific uptake are unknown. Here, we assessed metabolite profiles in elderly women who were either female offspring from obese mothers (OOM) or offspring of lean mothers (OLM). Metabolic changes were tested for associations with metrics for insulin resistance. Methods: Thirty-seven elderly women were separated into elderly offspring from obese mothers (OOM; n = 17) and elderly offspring from lean/normal weight mothers (OLM; n = 20) groups. We measured plasma metabolites using proton nuclear magnetic resonance (1H-NMR) and insulin-dependent tissue-specific glucose uptake in skeletal muscle was assessed. Associations were made between metabolites and glucose uptake. Results: Compared to the OLM group, we found that the docosahexaenoic acid percentage of the total long-chain n-3 fatty acids (DHA/FA) was significantly lower in OOM (p = 0.015). DHA/FA associated significantly with skeletal muscle glucose uptake (GU) (p = 0.031) and the metabolizable glucose value derived from hyperinsulinemic-euglycemic clamp technique (M-value) in the OLM group only (p = 0.050). Conclusions: DHA/FA is associated with insulin-dependent skeletal muscle glucose uptake and this association is significantly weakened in the offspring of obese mothers. View Full-Text
Keywords: 22:6 docosahexaenoic acid; ω-3 fatty acids; offspring of obese mothers; offspring of lean mothers; insulin-dependent skeletal muscle glucose uptake 22:6 docosahexaenoic acid; ω-3 fatty acids; offspring of obese mothers; offspring of lean mothers; insulin-dependent skeletal muscle glucose uptake
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MDPI and ACS Style

Badeau, R.M.; Honka, M.-J.; Bucci, M.; Iozzo, P.; Eriksson, J.G.; Nuutila, P. Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers. Nutrients 2017, 9, 110.

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