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Nutrients 2017, 9(12), 1324; doi:10.3390/nu9121324

Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models

1
College of Pharmacy, Pusan National University, Busan 46241, Korea
2
Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 26 October 2017 / Revised: 28 November 2017 / Accepted: 29 November 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Nutraceuticals and the Skin: Roles in Health and Disease)
View Full-Text   |   Download PDF [2162 KB, uploaded 5 December 2017]   |  

Abstract

Dioscorea quinqueloba has been used for food substances, as well as in herbal medicines for allergic diseases such as asthma. This study aimed to investigate the anti-atopic dermatitis (AD) effects of the total extract of D. quinqueloba rhizomes and active fractionson murine oxazolone- and 2,4-dinitrochlorobenzene-induced models of AD. Specific AD symptoms, such as erythema, ear swelling, and epidermis thickening, were significantly reduced in the oxazolone-mediated AD BALB/c mice upon topical application of D. quinqueloba rhizomes 95% EtOH extract (DQ). DQEA (D. quinqueloba rhizomes EtOAc fraction) was beneficial for protecting the skin barrier against AD in DNCB-sensitized SKH-1 hairless mice. Decreased total serum IgE and IL-4 levels could be observed in atopic dorsal skin samples of the DQEA-treated group. On the basis of the phytochemical analysis, DQEA was found to contain dioscin and gracillin as its main compounds. Therapeutic applications with D. quinqueloba might be useful in the treatment of AD and related inflammatory skin diseases. View Full-Text
Keywords: Dioscorea quinqueloba; atopic dermatitis; transepidermal water loss; skin hydration; interleukin 4; immunoglobulin E Dioscorea quinqueloba; atopic dermatitis; transepidermal water loss; skin hydration; interleukin 4; immunoglobulin E
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jegal, J.; Park, N.-J.; Bong, S.-K.; Jegal, H.; Kim, S.-N.; Yang, M.H. Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models. Nutrients 2017, 9, 1324.

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