Next Article in Journal
The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements
Previous Article in Journal
A Cross-Sectional Study of Nutrient Intake and Health Status among Older Adults in Yogyakarta Indonesia
Previous Article in Special Issue
The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(11), 1239; doi:10.3390/nu9111239

Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study

1
Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway
2
Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, 0167 Oslo, Norway
3
Department of Research and Development, TINE SA, 0902 Oslo, Norway
4
Division of Mental and Physical Health, Norwegian Institute of Public Health, 0456 Oslo, Norway
5
Section of Health, Developmental and Personality Psychology, Department of Psychology, University of Oslo, 0315 Oslo, Norway
6
Pharmaco Epidemiology and Drug Safety Research Group, School of Pharmacy, University of Oslo, 0315 Oslo, Norway
7
Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway
*
Author to whom correspondence should be addressed.
Received: 10 October 2017 / Revised: 3 November 2017 / Accepted: 8 November 2017 / Published: 13 November 2017
(This article belongs to the Special Issue Iodine and Health throughout the Lifecourse)
View Full-Text   |   Download PDF [1197 KB, uploaded 13 November 2017]   |  

Abstract

Current knowledge about the relationship between mild to moderately inadequate maternal iodine intake and/or supplemental iodine on child neurodevelopment is sparse. Using information from 77,164 mother-child pairs in the Norwegian Mother and Child Cohort Study, this study explored associations between maternal iodine intake and child attention-deficit/hyperactivity disorder (ADHD) diagnosis, registered in the Norwegian Patient Registry and maternally-reported child ADHD symptoms at eight years of age. Pregnant women reported food and supplement intakes by questionnaire in gestational week 22. In total, 1725 children (2.2%) were diagnosed with ADHD. In non-users of supplemental iodine (53,360 mothers), we found no association between iodine intake from food and risk of child ADHD diagnosis (p = 0.89), while low iodine from food (<200 µg/day) was associated with higher child ADHD symptom scores (adjusted difference in score up to 0.08 standard deviation (SD), p < 0.001, n = 19,086). In the total sample, we found no evidence of beneficial effects of maternal use of iodine-containing supplements (n = 23,804) on child ADHD diagnosis or symptom score. Initiation of iodine supplement use in gestational weeks 0–12 was associated with an increased risk of child ADHD (both measures). In conclusion, insufficient maternal iodine intake was associated with increased child ADHD symptom scores at eight years of age, but not with ADHD diagnosis. No reduction of risk was associated with maternal iodine supplement use. View Full-Text
Keywords: ADHD; attention-deficit/hyperactivity disorder; iodine; dietary supplements; pregnancy; neurodevelopment; Norwegian mother and child cohort study; MoBa; Norwegian Patient Registry ADHD; attention-deficit/hyperactivity disorder; iodine; dietary supplements; pregnancy; neurodevelopment; Norwegian mother and child cohort study; MoBa; Norwegian Patient Registry
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Abel, M.H.; Ystrom, E.; Caspersen, I.H.; Meltzer, H.M.; Aase, H.; Torheim, L.E.; Askeland, R.B.; Reichborn-Kjennerud, T.; Brantsæter, A.L. Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study. Nutrients 2017, 9, 1239.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top