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Nutrients 2017, 9(11), 1234; doi:10.3390/nu9111234

Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement

Azienda Ospedaliero Universitaria Città della Salute e della Scienza, S.C. Pneumologia U, 10126 Torino, Italy
Department of Medical Sciences, University of Turin, 10126 Turin, Italy
Both authors contributed equally to the manuscript.
Author to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 7 November 2017 / Accepted: 8 November 2017 / Published: 11 November 2017
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Background: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL. Methods: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients. Patients with deficiency were evaluated again after one year vitamin supplementation. Results: 25-OHD was low in 111 patients and was negatively related to exacerbations (p < 0.001), inhaled CS dose (p = 0.008) and asthma severity (p = 0.001). Deficiency was found in 90 patients, 55 of whom took the supplement regularly for one year, while 24 discontinued the study and 11 were not adherent. Patients with vitamin D deficiency after 12 months supplementation showed significant decrease of exacerbations (from 2.6 ± 1.2 to 1.6 ± 1.1, p < 0.001), circulating eosinophils (from 395 ± 330 to 272 ± 212 106/L, p < 0.001), and need of oral CS courses (from 35 to 20, p = 0.007) and improvement of airway obstruction. Conclusions: Asthma exacerbations are favored by vitamin D deficiency and decrease after long-term vitamin D replacement. Patients who are vitamin D deficient benefit from vitamin D supplementation. View Full-Text
Keywords: vitamin D deficiency; asthma exacerbations; airway obstruction; vitamin D supplementation vitamin D deficiency; asthma exacerbations; airway obstruction; vitamin D supplementation

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Solidoro, P.; Bellocchia, M.; Aredano, I.; Mattei, A.; Pivetta, E.; Patrucco, F.; Boita, M.; de Blasio, F.; Brussino, L.; Rolla, G.; Bucca, C. Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement. Nutrients 2017, 9, 1234.

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