Next Article in Journal
Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study
Previous Article in Journal
Integrated Evaluation of the Potential Health Benefits of Einkorn-Based Breads
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(11), 1234; doi:10.3390/nu9111234

Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement

1
Azienda Ospedaliero Universitaria Città della Salute e della Scienza, S.C. Pneumologia U, 10126 Torino, Italy
2
Department of Medical Sciences, University of Turin, 10126 Turin, Italy
Both authors contributed equally to the manuscript.
*
Author to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 7 November 2017 / Accepted: 8 November 2017 / Published: 11 November 2017
View Full-Text   |   Download PDF [969 KB, uploaded 11 November 2017]   |  

Abstract

Background: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL. Methods: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients. Patients with deficiency were evaluated again after one year vitamin supplementation. Results: 25-OHD was low in 111 patients and was negatively related to exacerbations (p < 0.001), inhaled CS dose (p = 0.008) and asthma severity (p = 0.001). Deficiency was found in 90 patients, 55 of whom took the supplement regularly for one year, while 24 discontinued the study and 11 were not adherent. Patients with vitamin D deficiency after 12 months supplementation showed significant decrease of exacerbations (from 2.6 ± 1.2 to 1.6 ± 1.1, p < 0.001), circulating eosinophils (from 395 ± 330 to 272 ± 212 106/L, p < 0.001), and need of oral CS courses (from 35 to 20, p = 0.007) and improvement of airway obstruction. Conclusions: Asthma exacerbations are favored by vitamin D deficiency and decrease after long-term vitamin D replacement. Patients who are vitamin D deficient benefit from vitamin D supplementation. View Full-Text
Keywords: vitamin D deficiency; asthma exacerbations; airway obstruction; vitamin D supplementation vitamin D deficiency; asthma exacerbations; airway obstruction; vitamin D supplementation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Solidoro, P.; Bellocchia, M.; Aredano, I.; Mattei, A.; Pivetta, E.; Patrucco, F.; Boita, M.; de Blasio, F.; Brussino, L.; Rolla, G.; Bucca, C. Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement. Nutrients 2017, 9, 1234.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top