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Nutrients 2017, 9(11), 1201; doi:10.3390/nu9111201

Epigenetic Regulatory Mechanisms Induced by Resveratrol

1
School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800903 Araraquara, Brazil
2
Institute of Chemistry, São Paulo State University (UNESP), 14800060 Araraquara, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 11 August 2017 / Revised: 5 September 2017 / Accepted: 18 September 2017 / Published: 1 November 2017
(This article belongs to the Special Issue Effects of Resveratrol Supplementation on Human Health and Disease)
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Abstract

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1). View Full-Text
Keywords: resveratrol; epigenetic targets; histone deacetylase; SIRT1; DNA methyltransferase; histone acetyltransferase resveratrol; epigenetic targets; histone deacetylase; SIRT1; DNA methyltransferase; histone acetyltransferase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fernandes, G.F.S.; Silva, G.D.B.; Pavan, A.R.; Chiba, D.E.; Chin, C.M.; Dos Santos, J.L. Epigenetic Regulatory Mechanisms Induced by Resveratrol. Nutrients 2017, 9, 1201.

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