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Nutrients 2017, 9(10), 1072; doi:10.3390/nu9101072

Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide

1
Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology and Hepatology, University of Antwerp, 2610 Antwerp, Belgium
2
Department of Gastroenterology and Hepatology, Antwerp University Hospital, 2650 Edegem, Belgium
*
Author to whom correspondence should be addressed.
Received: 15 August 2017 / Revised: 13 September 2017 / Accepted: 25 September 2017 / Published: 27 September 2017
(This article belongs to the Special Issue Nutrition and Non-alcoholic Fatty Liver Disease)
View Full-Text   |   Download PDF [253 KB, uploaded 27 September 2017]   |  

Abstract

Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the increasing incidence of obesity and diabetes in many Western countries, reaching a prevalence of up to 30% in the general population. Animal models have played a vital role in elucidating the pathophysiological mechanisms of NAFLD and continue to do so. A myriad of different models exists, each with its advantages and disadvantages. This review presents a brief overview of these models with a particular focus on the basic mechanisms and physical, biochemical and histological phenotype. Both nutritional and chemically induced, as well as genetic models are examined, including models combining different approaches. View Full-Text
Keywords: nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; animal model; mouse; rat; hepatocellular carcinoma; high-fat diet; fibrosis nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; animal model; mouse; rat; hepatocellular carcinoma; high-fat diet; fibrosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Van Herck, M.A.; Vonghia, L.; Francque, S.M. Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide. Nutrients 2017, 9, 1072.

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