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Nutrients 2017, 9(10), 1067; doi:10.3390/nu9101067

Serum Concentration of Leptin in Pregnant Adolescents Correlated with Gestational Weight Gain, Postpartum Weight Retention and Newborn Weight/Length

1
Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Secretaría de Salud, 11000 Ciudad de México, Mexico
2
Sección de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, 11340 Ciudad de México, Mexico
3
Coordinación de Medicina Laboral, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) “Dr. Manuel Martínez Báez”, Secretaría de Salud, 01480 Ciudad de México, Mexico
4
Subdirección de Investigación en Intervenciones Comunitarias del Instituto Nacional de Perinatología, Secretaría de Salud, 11000 Ciudad de México, Mexico
5
Universidad del Valle de México, Chapultepec, 11810 Ciudad de México, Mexico
*
Author to whom correspondence should be addressed.
Received: 5 August 2017 / Revised: 6 September 2017 / Accepted: 12 September 2017 / Published: 27 September 2017
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Abstract

Introduction: Gestational weight gain is an important modifiable factor known to influence fetal outcomes including birth weight and adiposity. Leptin is normally correlated with adiposity and is also known to increase throughout pregnancy, as the placenta becomes a source of leptin synthesis. Several studies have reported positive correlations between cord blood leptin level and either birthweight or size for gestational age, as well as body mass index (BMI). Objective: To determine the correlation of prenatal leptin concentration in pregnant adolescents with their gestational weight gain, postpartum weight retention, and weight/length of their newborn. Methods: A cohort study was conducted on pregnant Mexican adolescents from Gestational Week 26–28 to three months postpartum (n = 168 mother–child dyads). An anthropometric assessment was made of each pregnant adolescent, and the serum level of leptin and the intake of energy were determined. The newborn was evaluated each month during postpartum. Clinical records were reviewed to obtain sociodemographic data. Bivariate correlations, tests for repeating measurements and logistic regression models were performed. Results: Leptin concentration gradually increased during the third trimester of pregnancy. At Gestation Week 36, leptin level correlated with gestational weight gain. When comparing adolescents that had the lowest and highest concentration of leptin, the former presented a mean of 6 kg less in gestational weight gain (inter-subject leptin concentration, p = 0.001; inter-subject energy intake, p = 0.497). Leptin concentration and gestational weight gain exerted an effect on the weight of the newborn (inter-subject leptin concentration for Week 32, p = 0.024; inter-subject gestational weight gain, p = 0.011). Newborn length was associated with leptin concentration at Week 28 (leptin effect, p = 0.003; effect of gestational weight gain, p = 0.722). Conclusions: Pregnant adolescents with leptin concentration over 20 ng/mL showed a greater gestational weight gain. Leptin concentration correlated with length and weight of the newborn. View Full-Text
Keywords: Leptin; adolescent pregnancy; pregestational body mass index gestational; weight gain; birth weight Leptin; adolescent pregnancy; pregestational body mass index gestational; weight gain; birth weight
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MDPI and ACS Style

Sámano, R.; Martínez-Rojano, H.; Chico-Barba, G.; Godínez-Martínez, E.; Sánchez-Jiménez, B.; Montiel-Ojeda, D.; Tolentino, M. Serum Concentration of Leptin in Pregnant Adolescents Correlated with Gestational Weight Gain, Postpartum Weight Retention and Newborn Weight/Length. Nutrients 2017, 9, 1067.

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