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Nutrients 2017, 9(10), 1052; doi:10.3390/nu9101052

Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease

1
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Campus Sescelades, Tarragona 43007, Spain
2
Technological Unit of Nutrition and Health, EURECAT-Technology Centre of Catalonia, Avinguda Universitat 1, Reus 43204, Spain
*
Author to whom correspondence should be addressed.
Received: 25 July 2017 / Revised: 1 September 2017 / Accepted: 11 September 2017 / Published: 22 September 2017
(This article belongs to the Special Issue Nutrition and Non-alcoholic Fatty Liver Disease)
View Full-Text   |   Download PDF [358 KB, uploaded 22 September 2017]

Abstract

Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of hepatic disorders, from simple steatosis to hepatic necro-inflammation leading to non-alcoholic steatohepatitis (NASH). Although the prevalence of these multifactorial pathologies is continuously increasing in the population, there is still not an established methodology for their treatment other than weight loss and a change in lifestyle habits, such as a hypocaloric diet and physical exercise. In this framework, there is increasing evidence that several food bioactives and dietary patterns are effective for reversing and preventing the onset of these pathologies. Some studies have claimed that better responses are obtained when treatments are performed under a multifaceted approach, using different bioactive compounds that act against complementary targets. Thus, in this work, current strategies for treating NAFLD and NASH based on multi-ingredient-based supplements or the Mediterranean diet, a dietary pattern rich in bioactive compounds, are reviewed. Furthermore, the usefulness of omics techniques to design effective multi-ingredient nutritional interventions and to predict and monitor their response against these disorders is also discussed. View Full-Text
Keywords: non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatic steatosis; Mediterranean diet; multi-ingredient; polyunsaturated fatty acids; vitamins; synbiotics; silymarin; omics technologies non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatic steatosis; Mediterranean diet; multi-ingredient; polyunsaturated fatty acids; vitamins; synbiotics; silymarin; omics technologies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Suárez, M.; Boqué, N.; del Bas, J.M.; Mayneris-Perxachs, J.; Arola, L.; Caimari, A. Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease. Nutrients 2017, 9, 1052.

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