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Nutrients 2017, 9(1), 11; doi:10.3390/nu9010011

High Dietary Fructose Intake on Cardiovascular Disease Related Parameters in Growing Rats

1
Department of Medical Nutrition, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, Korea
2
Research Institute of Medical Nutrition, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
Received: 29 October 2016 / Revised: 7 December 2016 / Accepted: 15 December 2016 / Published: 26 December 2016
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Abstract

The objective of this study was to determine the effects of a high-fructose diet on cardiovascular disease (CVD)-related parameters in growing rats. Three-week-old female Sprague Dawley rats were randomly assigned to four experimental groups; a regular diet group (RD: fed regular diet based on AIN-93G, n = 8), a high-fructose diet group (30Frc: fed regular diet with 30% fructose, n = 8), a high-fat diet group (45Fat: fed regular diet with 45 kcal% fat, n = 8) or a high fructose with high-fat diet group (30Frc + 45Fat, fed diet 30% fructose with 45 kcal% fat, n = 8). After an eight-week treatment period, the body weight, total-fat weight, serum glucose, insulin, lipid profiles and pro-inflammatory cytokines, abdominal aortic wall thickness, and expressions of eNOS and ET-1 mRNA were analyzed. The result showed that total-fat weight was higher in the 30Frc, 45Fat, and 30Frc + 45Fat groups compared to the RD group (p < 0.05). Serum triglyceride (TG) levels were highest in the 30Frc group than the other groups (p < 0.05). The abdominal aorta of 30Frc, 45Fat, and 30Frc + 45Fat groups had higher wall thickness than the RD group (p < 0.05). Abdominal aortic eNOS mRNA level was decreased in 30Frc, 45Fat, and 30Frc + 45Fat groups compared to the RD group (p < 0.05), and also 45Fat and 30Frc + 45Fat groups had decreased mRNA expression of eNOS compared to the 30Frc group (p < 0.05). ET-1 mRNA level was higher in 30Frc, 45Fat, and 30Frc + 45Fat groups than the RD group (p < 0.05). Both high fructose consumption and high fat consumption in growing rats had similar negative effects on CVD-related parameters. View Full-Text
Keywords: high fructose diet; cardiovascular disease (CVD); growing rat high fructose diet; cardiovascular disease (CVD); growing rat
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Yoo, S.; Ahn, H.; Park, Y.K. High Dietary Fructose Intake on Cardiovascular Disease Related Parameters in Growing Rats. Nutrients 2017, 9, 11.

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