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Nutrients 2016, 8(9), 579; doi:10.3390/nu8090579

The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study

1
School of Psychology, Social Work and Social Policy, University of South Australia, Adelaide 5001, Australia
2
Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Health Sciences, University of South Australia, Adelaide 5001, Australia
3
Flinders Centre for Innovation in Cancer, School of Medicine, The Flinders University of South Australia, G.P.O. Box 2100, Adelaide 5001, Australia
4
School of Medicine and Pharmacology, The University of Western Australia, Perth 6000, Australia
*
Author to whom correspondence should be addressed.
Received: 15 July 2016 / Revised: 2 September 2016 / Accepted: 13 September 2016 / Published: 20 September 2016
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Abstract

Evidence from a limited number of randomised controlled intervention trials (RCTs) have shown that a Mediterranean dietary pattern may reduce the risk of cognitive decline and enhance cognitive function among healthy older adults. However, there are currently no data in non-Mediterranean older adult populations. The present study aimed to address this gap by examining the effect of a Mediterranean dietary pattern (MedDiet) for six months on aspects of cognitive function in a randomised controlled intervention trial (the MedLey study) that extended for a duration of 18 months. In the final analysed cohort, a total of 137 men and women (mean age of 72.1 ± 5.0 years) randomly assigned to either a MedDiet or control diet (HabDiet) (i.e., habitual dietary intake), were assessed on a comprehensive neuropsychological test battery, including 11 individual tests. In multivariable-adjusted models, the MedDiet group did not perform significantly better than the HabDiet control group for executive functioning (adjusted mean differences: +2.53, 95% CI −2.59 to 7.65, p = 0.33); speed of processing (adjusted mean differences: +3.24, 95% CI −1.21 to 7.70, p = 0.15); memory (adjusted mean differences: +2.00, 95% CI −3.88 to 7.88, p = 0.50); visual-spatial ability (adjusted mean differences: +0.21, 95% CI −0.38 to 0.81, 0.48); and overall age-related cognitive performance (adjusted mean differences: +7.99, 95% CI −4.00 to 19.9, p = 0.19). In conclusion, this study did not find evidence of a beneficial effect of a MedDiet intervention on cognitive function among healthy older adults. View Full-Text
Keywords: Mediterranean diet; cognitive function; randomised controlled trial; older adults Mediterranean diet; cognitive function; randomised controlled trial; older adults
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MDPI and ACS Style

Knight, A.; Bryan, J.; Wilson, C.; Hodgson, J.M.; Davis, C.R.; Murphy, K.J. The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study. Nutrients 2016, 8, 579.

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