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Nutrients 2016, 8(9), 573; doi:10.3390/nu8090573

The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein

1
Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico
2
Centre de Recherche du Chu de Québec, Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Faculté de Médicine, Université Laval, Québec City, QC G1V 0A6, Canada
3
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
*
Author to whom correspondence should be addressed.
Received: 13 July 2016 / Revised: 19 August 2016 / Accepted: 12 September 2016 / Published: 20 September 2016
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Abstract

Between 6% and 11% of the world’s population suffers from malnutrition or undernutrition associated with poverty, aging or long-term hospitalization. The present work examined the effect of different types of proteins on the mechanistic target of rapamycin (mTORC1)-signaling pathway in: (1) healthy; and (2) protein restricted rats. (1) In total, 200 rats were divided into eight groups and fed one of the following diets: 20% casein (C), soy (S), black bean (B), B + Corn (BCr), Pea (P), spirulina (Sp), sesame (Se) or Corn (Cr). Rats fed C or BCr had the highest body weight gain; rats fed BCr had the highest pS6K1/S6K1 ratio; rats fed B, BCr or P had the highest eIF4G expression; (2) In total, 84 rats were fed 0.5% C for 21 day and protein rehabilitated with different proteins. The S, soy + Corn (SCr) and BCr groups had the highest body weight gain. Rats fed SCr and BCr had the highest eIF4G expression and liver polysome formation. These findings suggest that the quality of the dietary proteins modulate the mTORC1-signaling pathway. In conclusion, the combination of BCr or SCr are the best proteins for dietary protein rehabilitation due to the significant increase in body weight, activation of the mTORC1-signaling pathway in liver and muscle, and liver polysome formation. View Full-Text
Keywords: soy protein; black bean protein; SNAT2; mTORC1-signaling pathway; polysome profiling; protein rehabilitation soy protein; black bean protein; SNAT2; mTORC1-signaling pathway; polysome profiling; protein rehabilitation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Márquez-Mota, C.C.; Rodriguez-Gaytan, C.; Adjibade, P.; Mazroui, R.; Gálvez, A.; Granados, O.; Tovar, A.R.; Torres, N. The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein. Nutrients 2016, 8, 573.

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