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Nutrients 2016, 8(9), 564; doi:10.3390/nu8090564

Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

1
College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
2
Institute of Agricultural Quality Standards and Testing Technology Research, Shandong Academy of Agricultural Sciences, Jinan 250100, China
3
College of Life Sciences, Tianjin Normal University, Tianjin 300387, China
4
Institute of Agro-Products Quality Testing, Jinan Academy of Agricultural Sciences, Jinan 250316, China
5
Food and Biological Technology Department, Guangxi Polytechnic College, Nanning 530226, China
6
Veterans Affairs Boston Healthcare System, Department of Neurology, Harvard Medical School, West Roxbury, MA 02132, USA
*
Authors to whom correspondence should be addressed.
Received: 15 July 2016 / Revised: 3 September 2016 / Accepted: 7 September 2016 / Published: 19 September 2016
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Abstract

The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)—a famous longevous region—and elderly people aged 80–99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = −0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity. View Full-Text
Keywords: centenarian; nutrient intake; metabolite; element; longevous region; pattern recognition; partial least squares-discriminant analysis centenarian; nutrient intake; metabolite; element; longevous region; pattern recognition; partial least squares-discriminant analysis
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MDPI and ACS Style

Cai, D.; Zhao, S.; Li, D.; Chang, F.; Tian, X.; Huang, G.; Zhu, Z.; Liu, D.; Dou, X.; Li, S.; Zhao, M.; Li, Q. Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians. Nutrients 2016, 8, 564.

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