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Nutrients 2016, 8(8), 497; doi:10.3390/nu8080497

Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis

1
Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China
2
Department of Physics and Chemistry, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300070, China
3
Department of Rehabilitation and Sports Medicine, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China
4
Community Health Service Center for Shuangjie Town of Beichen District in Tianjin, Zhangwan Road, Shuangjie Town, Beichen District, Tianjin 300400, China
*
Author to whom correspondence should be addressed.
Received: 20 May 2016 / Revised: 30 July 2016 / Accepted: 8 August 2016 / Published: 13 August 2016
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Abstract

Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the associations of serum manganese with prediabetes and diabetes. Serum manganese levels were measured using inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate the sex-specific associations of manganese levels with diabetes and prediabetes after adjusting for confounding factors (age, sex, life style factors, and health status). Based on the WHO criteria, prediabetes was observed in 15.1% of men and 13.4% of women, while diabetes was observed in 30.0% of men and 34.4% of women. In the final model, the odds ratios (95% confidence interval) for prediabetes according to manganese quartile were 1.000, 0.463 (0.269–0.798), 0.639 (0.383–1.065), and 0.614 (0.365–1.031) among men and 1.000, 0.773 (0.498–1.200), 0.602 (0.382–0.947), and 0.603 (0.381–0.953) among women (p for trend = 0.134 and 0.015, respectively). The lowest prevalence of diabetes among men occurred at a moderate range of serum manganese (p < 0.05). Therefore, appropriate serum manganese levels may help prevent and control prediabetes and diabetes. View Full-Text
Keywords: manganese; prediabetes; diabetes; older adult manganese; prediabetes; diabetes; older adult
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, X.; Zhang, M.; Lui, G.; Chang, H.; Zhang, M.; Liu, W.; Li, Z.; Liu, Y.; Huang, G. Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis. Nutrients 2016, 8, 497.

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