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Nutrients 2016, 8(8), 457; doi:10.3390/nu8080457

The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians

1
Health Promotion & Disease Prevention, School of Public Health, Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth 6102, Australia
2
Occupation and the Environnent, School of Public Health, Faculty of Health Sciences, Curtin University, Perth 6102, Australia
3
University Health Service, Support Services, Curtin University, Perth 6102, Australia
*
Author to whom correspondence should be addressed.
Received: 30 April 2016 / Revised: 11 July 2016 / Accepted: 22 July 2016 / Published: 28 July 2016
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
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Abstract

Background/Aims: Vitamin D has been investigated for many non-skeletal effects. The objective of this study was to determine whether circulating lipids, systemic inflammation, and biomarkers of endothelial cell activation varied with the vitamin D status of older Australians. Methods: One hundred and one participants were proportionately and randomly sampled across tertiles of 25 hydroxy vitamin D (25(OH)D) from a larger cohort of free living older adults (T1 median = 97; T2 median = 74.5; T3 median = 56.8 nmol/L). Overnight fasting blood samples were assayed for 25(OH)D, parathyroid hormone (PTH), insulin, triacylglycerol (TAG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C). Markers of systemic inflammation (high sensitivity C-reactive protein (hsCRP), tumour necrosis factor-α (TNF-α)) and endothelial activation (hepatocyte growth factor (HGF), P-selectin and soluble vascular cell adhesion molecule (sVCAM), soluble intracellular adhesion molecule (sICAM)) were determined. A general linear model multivariate analysis with a backward elimination procedure was performed. Results: Eighty-three participants (48 women, 35 men), aged 65 ± 7.7 years, BMI 28 ± 4.5 kg/m2, with complete data were analyzed. The final parsimonious model controlled for age, gender, BMI, and McAuley’s index, but excluded season, medications, and PTH. There were significant differences across 25(OH)D tertiles in TC (T1 < T3, p = 0.003; T2 < T3, p = 0.001), LDL-C (T1 < T3, p = 0.005; T2 < T3, p = 0.001), TAG (T2 < T3, p = 0.026), HGF (T1 > T3, p = 0.009) and sVCAM (T1 > T3, P = 0.04). Conclusions: Higher vitamin D status may protect the endothelium through reduced dyslipidaemia and increased HGF. View Full-Text
Keywords: vitamin D; endothelial function; inflammation; cardiovascular disease; lipids vitamin D; endothelial function; inflammation; cardiovascular disease; lipids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Alyami, A.M.; Lam, V.; Soares, M.J.; Zhao, Y.; Sherriff, J.L.; Mamo, J.C.; James, A.P.; Coombes, F. The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians. Nutrients 2016, 8, 457.

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