Next Article in Journal
Curcumin AntiCancer Studies in Pancreatic Cancer
Next Article in Special Issue
Metabolically Healthy Overweight and Obesity Is Associated with Higher Adherence to a Traditional Dietary Pattern: A Cross-Sectional Study among Adults in Lebanon
Previous Article in Journal
Quercitrin from Toona sinensis (Juss.) M.Roem. Attenuates Acetaminophen-Induced Acute Liver Toxicity in HepG2 Cells and Mice through Induction of Antioxidant Machinery and Inhibition of Inflammation
Previous Article in Special Issue
Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model
Article Menu

Export Article

Open AccessArticle
Nutrients 2016, 8(7), 430; doi:10.3390/nu8070430

Natural Course of Metabolically Healthy Overweight/Obese Subjects and the Impact of Weight Change

1
Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China
2
Department of Endocrinology and Institute of Cardiovascular Diseases, Zhejiang Putuo Hospital, Zhoushan 316100, Zhejiang, China
3
Tongxiang Center for Disease Control and Prevention, Tongxiang 314500, Zhejiang, China
4
Institute of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310000, Zhejiang, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 19 May 2016 / Revised: 8 July 2016 / Accepted: 11 July 2016 / Published: 15 July 2016
(This article belongs to the Special Issue Metabolically Healthy Obesity)
View Full-Text   |   Download PDF [406 KB, uploaded 15 July 2016]   |  

Abstract

Few studies have described the characteristics of metabolically healthy individuals with excess fat in the Chinese population. This study aimed to prospectively investigate the natural course of metabolically healthy overweight/obese (MH-OW/OB) adults, and to assess the impact of weight change on developing metabolic abnormalities. During 2009–2010, 525 subjects without any metabolic abnormalities or other obesity-related diseases were evaluated and reevaluated after 5 years. The subjects were categorized into two groups of overweight/obese and normal weight based on the criteria of BMI by 24.0 at baseline. At follow-up, the MH-OW/OB subjects had a significantly increased risk of developing metabolically abnormalities compared with metabolically healthy normal-weight (MH-NW) individuals (risk ratio: 1.35, 95% confidence interval: 1.17–1.49, p value < 0.001). In the groups of weight gain and weight maintenance, the MH-OW/OB subjects was associated with a larger increase in fasting glucose, triglycerides, systolic blood pressure, diastolic blood pressure and decrease in high-density lipoprotein cholesterol comparing with MH-NW subjects. In the weight loss group, no significant difference of changes of metabolic parameters was observed between MH-OW/OB and MH-NW adults. This study verifies that MH-OW/OB are different from MH-NW subjects. Weight management is needed for all individuals since weight change has a significant effect on metabolic health without considering the impact of weight change according to weight status. View Full-Text
Keywords: metabolically healthy; overweight and obese; weight change metabolically healthy; overweight and obese; weight change
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zheng, R.; Liu, C.; Wang, C.; Zhou, B.; Liu, Y.; Pan, F.; Zhang, R.; Zhu, Y. Natural Course of Metabolically Healthy Overweight/Obese Subjects and the Impact of Weight Change. Nutrients 2016, 8, 430.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top