Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells
AbstractAlzheimer’s disease (AD) is a neurodegenerative disease in humans. The accumulation of amyloid-β (Aβ) plays a critical role in the pathogenesis of AD. Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Aβ-induced memory impairment. However, whether SalB could influence the generation of Aβ is unclear. Here, we show that SalB (25, 50, or 100 µM) reduces the generation of Aβ40 and Aβ42 in culture media by decreasing the protein expressions of BACE1 and sAPPβ in SH-SY5Y-APPsw cells. Meanwhile, SalB increases the levels of ADAM10 and sAPPα in the cells. However, SalB has no impact on the protein expressions of APP and PS1. Moreover, SalB attenuates oxidative stress and inhibits the activity of GSK3β, which might be related to the suppression of BACE1 expression and amyloidogenesis. Our study suggests that SalB is a promising therapeutic agent for AD by targeting Aβ generation. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 670 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Tang, Y.; Huang, D.; Zhang, M.-H.; Zhang, W.-S.; Tang, Y.-X.; Shi, Z.-X.; Deng, L.; Zhou, D.-H.; Lu, X.-Y. Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells. Nutrients 2016, 8, 333.
Tang Y, Huang D, Zhang M-H, Zhang W-S, Tang Y-X, Shi Z-X, Deng L, Zhou D-H, Lu X-Y. Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells. Nutrients. 2016; 8(6):333.Chicago/Turabian Style
Tang, Ying; Huang, Dan; Zhang, Mei-Hua; Zhang, Wen-Sheng; Tang, Yu-Xin; Shi, Zheng-Xiang; Deng, Li; Zhou, Dai-Han; Lu, Xin-Yi. 2016. "Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells." Nutrients 8, no. 6: 333.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.