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Nutrients 2016, 8(6), 333; doi:10.3390/nu8060333

Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells

1
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
2
Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226361, China
3
Nantong Tumor Hospital, Nantong 226361, China
4
Rugao Changjiang Hospital, Nantong 226532, China
5
Maternal and Child Health Hospital of Zhoushan, Zhoushan 316000, China
6
Zhoushan Hospital, Zhoushan 316004, China
7
Guangzhou Hospital of TCM, Guangzhou 510130, China
8
Biological Resource Center, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 March 2016 / Revised: 27 April 2016 / Accepted: 24 May 2016 / Published: 1 June 2016
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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease in humans. The accumulation of amyloid-β (Aβ) plays a critical role in the pathogenesis of AD. Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Aβ-induced memory impairment. However, whether SalB could influence the generation of Aβ is unclear. Here, we show that SalB (25, 50, or 100 µM) reduces the generation of Aβ40 and Aβ42 in culture media by decreasing the protein expressions of BACE1 and sAPPβ in SH-SY5Y-APPsw cells. Meanwhile, SalB increases the levels of ADAM10 and sAPPα in the cells. However, SalB has no impact on the protein expressions of APP and PS1. Moreover, SalB attenuates oxidative stress and inhibits the activity of GSK3β, which might be related to the suppression of BACE1 expression and amyloidogenesis. Our study suggests that SalB is a promising therapeutic agent for AD by targeting Aβ generation. View Full-Text
Keywords: Alzheimer’s disease; Salvianolic acid B; Aβ generation; BACE1; oxidative stress; GSK3β Alzheimer’s disease; Salvianolic acid B; Aβ generation; BACE1; oxidative stress; GSK3β
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tang, Y.; Huang, D.; Zhang, M.-H.; Zhang, W.-S.; Tang, Y.-X.; Shi, Z.-X.; Deng, L.; Zhou, D.-H.; Lu, X.-Y. Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells. Nutrients 2016, 8, 333.

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