Role of Vitamin D in Cognitive Function in Chronic Kidney Disease
AbstractBoth vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and hyperlipidemia), inflammation, oxidative stress, immune suppression and neurocognitive impairment. The combination of hypovitaminosis D and CKD can be even more debilitating, as cognitive impairment can develop and progress through vitamin D-associated and CKD-dependent/independent processes, leading to significant morbidity and mortality. Although an increasingly recognized comorbidity in CKD, cognitive impairment remains underdiagnosed and often undermanaged. Given the association of cognitive decline and hypovitaminosis D and their deleterious effects in CKD patients, determination of vitamin D status and when appropriate, supplementation, in conjunction with neuropsychological screening, should be considered integral to the clinical care of the CKD population. View Full-Text
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Cheng, Z.; Lin, J.; Qian, Q. Role of Vitamin D in Cognitive Function in Chronic Kidney Disease. Nutrients 2016, 8, 291.
Cheng Z, Lin J, Qian Q. Role of Vitamin D in Cognitive Function in Chronic Kidney Disease. Nutrients. 2016; 8(5):291.Chicago/Turabian Style
Cheng, Zhen; Lin, Jing; Qian, Qi. 2016. "Role of Vitamin D in Cognitive Function in Chronic Kidney Disease." Nutrients 8, no. 5: 291.
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