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Nutrients 2016, 8(5), 281; doi:10.3390/nu8050281

Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals

1
BioMed Research Center, Biological Sciences Department, University of Quebec at Montreal, Montreal, QC H2X 1Y4, Canada
2
Department of Exercise Science, University of Quebec at Montreal, Montreal, QC H2X 1Y4, Canada
*
Author to whom correspondence should be addressed.
Received: 31 March 2016 / Revised: 5 May 2016 / Accepted: 9 May 2016 / Published: 12 May 2016
(This article belongs to the Special Issue Metabolically Healthy Obesity)
View Full-Text   |   Download PDF [648 KB, uploaded 12 May 2016]   |  

Abstract

Obesity and associated metabolic complications, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D), are in constant increase around the world. While most obese patients show several metabolic and biometric abnormalities and comorbidities, a subgroup of patients representing 3% to 57% of obese adults, depending on the diagnosis criteria, remains metabolically healthy. Among many other factors, the gut microbiota is now identified as a determining factor in the pathogenesis of metabolically unhealthy obese (MUHO) individuals and in obesity-related diseases such as endotoxemia, intestinal and systemic inflammation, as well as insulin resistance. Interestingly, recent studies suggest that an optimal healthy-like gut microbiota structure may contribute to the metabolically healthy obese (MHO) phenotype. Here, we describe how dietary medium chain triglycerides (MCT), previously found to promote lipid catabolism, energy expenditure and weight loss, can ameliorate metabolic health via their capacity to improve both intestinal ecosystem and permeability. MCT-enriched diets could therefore be used to manage metabolic diseases through modification of gut microbiota. View Full-Text
Keywords: obesity; metabolically unhealthy obese; metabolically healthy obese; metabolic syndrome; non-alcoholic fatty liver disease; gut microbiota; Bacteroidetes; Firmicutes; endotoxemia; lipopolysaccharide; medium chain triglycerides; medium chain fatty acids obesity; metabolically unhealthy obese; metabolically healthy obese; metabolic syndrome; non-alcoholic fatty liver disease; gut microbiota; Bacteroidetes; Firmicutes; endotoxemia; lipopolysaccharide; medium chain triglycerides; medium chain fatty acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rial, S.A.; Karelis, A.D.; Bergeron, K.-F.; Mounier, C. Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals. Nutrients 2016, 8, 281.

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