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Nutrients 2016, 8(5), 275; doi:10.3390/nu8050275

The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium

1
Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Rome 00133, Italy
2
Internal Medicine Residency Program, University of Rome “Tor Vergata”, Rome 00133, Italy
3
Department of Experimental Medicine, University of Rome “Sapienza”, Rome 00164, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 March 2016 / Revised: 12 April 2016 / Accepted: 4 May 2016 / Published: 9 May 2016
(This article belongs to the Special Issue Polyphenols for Cancer Treatment or Prevention)
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Abstract

Malignant Mesothelioma (MM) is a tumor of the serous membranes linked to exposure to asbestos. A chronic inflammatory response orchestrated by mesothelial cells contributes to the development and progression of MM. The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells; (b) asbestos mediated-chronic inflammation has a key role in MM carcinogenesis; (c) the deregulation of the immune system might favor the development of MM; and (d) a drug might have a better efficacy when injected into a serous cavity thus bypassing biotransformation and reaching an effective dose has prompted investigations to evaluate the effects of polyphenols for the therapy and prevention of MM. Dietary polyphenols are able to inhibit cancer cell growth by targeting multiple signaling pathways, reducing inflammation, and modulating immune response. The ability of polyphenols to modulate the production of pro-inflammatory molecules by targeting signaling pathways or ROS might represent a key mechanism to prevent and/or to contrast the development of MM. In this review, we will report the current knowledge on the ability of polyphenols to modulate the immune system and production of mediators of inflammation, thus revealing an important tool in preventing and/or counteracting the growth of MM. View Full-Text
Keywords: malignant mesothelioma; inflammation; immune system; ROS and RNS; polyphenols; asbestos malignant mesothelioma; inflammation; immune system; ROS and RNS; polyphenols; asbestos
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Benvenuto, M.; Mattera, R.; Taffera, G.; Giganti, M.G.; Lido, P.; Masuelli, L.; Modesti, A.; Bei, R. The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium. Nutrients 2016, 8, 275.

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