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Nutrients 2016, 8(5), 151; doi:10.3390/nu8050151

Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C

1
Department of Veterinary Physiology, Ahmadu Bello University, c/o P.O. Box 216 Samaru, 810006 Zaria, Nigeria
2
Biochemistry Division, National Veterinary Research Institute, 930103 Vom, Nigeria
*
Author to whom correspondence should be addressed.
Received: 17 December 2015 / Revised: 16 February 2016 / Accepted: 1 March 2016 / Published: 5 May 2016
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Abstract

Clinical and experimental evidence suggests that hyperglycaemia is responsible for the oxidative stress in diabetes mellitus. The study was designed to investigate the comparative effects of probiotic and vitamin C (Vit-C) treatments on hyperglycaemia, oxidative stress and dyslipidaemia in alloxan-induced diabetic rats. Type 1 diabetes (T1DM) was induced in male Wistar rats by a single intraperitoneal (i.p.) injection of alloxan (150 mg/kg). Six groups of the animals received the following treatment regimens for four weeks: (1) Normal saline, per os; (2) alloxan (150 mg/kg, i.p.); (3) alloxan (150 mg/kg) + insulin (4 U/kg, subcutaneously); (4) alloxan (150 mg/kg) + probiotic (4.125 × 106 CFU/100 mL per os); (5) alloxan (150 mg/kg) + Vit-C (100 mg/kg, i.m.); (6) alloxan (150 mg/kg) + probiotic (4.125 × 106 CFU/100 mL per os) + Vit-C (100 mg/kg, intramuscularly). Probiotic + Vit-C decreased (p < 0.05) blood glucose concentration in diabetic treated group, when compared with the untreated diabetic group. Probiotic + Vit-C reduced malondialdehyde concentration, in the serum, brain and kidneys, respectively, but increased the activity of antioxidant enzymes. Probiotic and Vit-C may be more effective than Vit-C alone, in ameliorating hyperglycaemia, oxidative stress and dyslipidaemia in alloxan-induced diabetic rats. View Full-Text
Keywords: dyslipidaemia; hyperglycaemia; oxidative stress; type 1 diabetes; wistar rats dyslipidaemia; hyperglycaemia; oxidative stress; type 1 diabetes; wistar rats
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MDPI and ACS Style

Aluwong, T.; Ayo, J.O.; Kpukple, A.; Oladipo, O.O. Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C. Nutrients 2016, 8, 151.

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