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Nutrients 2016, 8(4), 214; doi:10.3390/nu8040214

Premenopausal Obesity and Breast Cancer Growth Rates in a Rodent Model

Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
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Received: 2 February 2016 / Revised: 29 March 2016 / Accepted: 31 March 2016 / Published: 11 April 2016
(This article belongs to the Special Issue Premenopausal Nutrition and Fertility)
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Abstract

Obese premenopausal women with breast cancer have poorer prognosis for long term survival, in part because their tumors are larger at the time of diagnosis than are found in normal weight women. Whether larger tumor mass is due to obesity-related barriers to detection or to effects on tumor biology is not known. This study used polygenic models for obesity and breast cancer to deconstruct this question with the objective of determining whether cell autonomous mechanisms contribute to the link between obesity and breast cancer burden. Assessment of the growth rates of 259 chemically induced mammary carcinomas from rats sensitive to dietary induced obesity (DS) and of 143 carcinomas from rats resistant (DR) to dietary induced obesity revealed that tumors in DS rats grew 1.8 times faster than in DR rats. This difference may be attributed to alterations in cell cycle machinery that permit more rapid tumor cell accumulation. DS tumors displayed protein expression patterns consistent with reduced G1/S checkpoint inhibition and a higher threshold of factors required for execution of the apoptotic cell death pathway. These mechanistic insights identify regulatory targets for life style modifications or pharmacological interventions designed to disrupt the linkage between obesity and tumor burden. View Full-Text
Keywords: apoptosis; breast cancer; cell proliferation; obesity; premenopausal; tumor growth apoptosis; breast cancer; cell proliferation; obesity; premenopausal; tumor growth
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Matthews, S.B.; McGinley, J.N.; Neil, E.S.; Thompson, H.J. Premenopausal Obesity and Breast Cancer Growth Rates in a Rodent Model. Nutrients 2016, 8, 214.

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