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Nutrients 2016, 8(3), 178; doi:10.3390/nu8030178

High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet

1
IMBICE (CICPBA-CONICET La Plata-National University of La Plata (UNLP)), La Plata 1900, Argentina
2
IIFP (CONICET La Plata) School of Exact Sciences, National University of La Plata (UNLP), La Plata1900, Argentina
3
CENEXA (CONICET La Plata-UNLP, a PAHO/WHO (Collaborating Centre for Diabetes)), School of Medicine, National University of La Plata (UNLP), La Plata1900, Argentina
*
Author to whom correspondence should be addressed.
Received: 29 December 2015 / Revised: 29 February 2016 / Accepted: 14 March 2016 / Published: 22 March 2016
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
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Abstract

The aim of this work was to determine the effect of a fructose rich diet (FRD) consumed by the pregnant mother on the endocrine-metabolic and in vivo and in vitro adipose tissue (AT) functions of the male offspring in adulthood. At 60 days of age, rats born to FRD-fed mothers (F) showed impaired glucose tolerance after glucose overload and high circulating levels of leptin (LEP). Despite the diminished mass of retroperitoneal AT, this tissue was characterized by enhanced LEP gene expression, and hypertrophic adipocytes secreting in vitro larger amounts of LEP. Analyses of stromal vascular fraction composition by flow cytometry revealed a reduced number of adipocyte precursor cells. Additionally, 60 day-old control (C) and F male rats were subjected to control diet (CC and FC animals) or FRD (CF and FF rats) for three weeks. FF animals were heavier and consumed more calories. Their metabolic-endocrine parameters were aggravated; they developed severe hyperglycemia, hypertriglyceridemia, hyperleptinemia and augmented AT mass with hypertrophic adipocytes. Our study highlights that manipulation of maternal diet induced an offspring phenotype mainly imprinted with a severely unhealthy adipogenic process with undesirable endocrine-metabolic consequences, putting them at high risk for developing a diabetic state. View Full-Text
Keywords: metabolic programming; adipocyte precursor cells; dysfunctional adipose tissue; altered glucose tolerance; insulin resistance; pre-diabetes; metabolic syndrome metabolic programming; adipocyte precursor cells; dysfunctional adipose tissue; altered glucose tolerance; insulin resistance; pre-diabetes; metabolic syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Alzamendi, A.; Zubiría, G.; Moreno, G.; Portales, A.; Spinedi, E.; Giovambattista, A. High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet. Nutrients 2016, 8, 178.

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