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Nutrients 2016, 8(3), 175; doi:10.3390/nu8030175

n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease

School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth 6000, Western Australia, Australia
CSIRO Food and Nutrition, Adelaide 5000, South Australia, Australia
Department of Nephrology and Transplantation, Fiona Stanley Hospital, Murdoch 6150, Western Australia, Australia
Telethon Kids Institute, Subiaco 6008, Western Australia, Australia
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 17 December 2015 / Revised: 8 March 2016 / Accepted: 17 March 2016 / Published: 19 March 2016
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DNA telomere shortening associates with the age-related increase cardiovascular disease (CVD) risk. Reducing oxidative stress, could modify telomere erosion during cell replication, and CVD risk in patients with chronic kidney disease (CKD). The effect of n-3 fatty acids and coenzyme Q10 (CoQ) on telomere length was studied in a double-blind placebo-controlled trial in CKD. Eighty-five CKD patients were randomized to: n-3 fatty acids (4 g); CoQ (200 mg); both supplements; or control (4 g olive oil), daily for 8 weeks. Telomere length was measured in neutrophils and peripheral blood mononuclear cells (PBMC) at baseline and 8 weeks, with and without correction for cell counts. Main and interactive effects of n-3 fatty acids and CoQ on telomere length were assessed adjusting for baseline values. F2-isoprostanes were measured as markers of oxidative stress. There was no effect of n-3 fatty acids or CoQ on neutrophil or PBMC telomere length. However, telomere length corrected for neutrophil count was increased after n-3 fatty acids (p = 0.015). Post-intervention plasma F2-isoprostanes were negative predictors of post-intervention telomere length corrected for neutrophil count (p = 0.025).The effect of n-3 fatty acids to increased telomere length corrected for neutrophil count may relate to reduced oxidative stress and increased clearance of neutrophils with shorter telomeres from the circulation. This may be a novel mechanism of modifying CVD risk in CKD patients. View Full-Text
Keywords: neutrophils; telomere length; oxidative stress; n-3 fatty acids; coenzyme Q10 neutrophils; telomere length; oxidative stress; n-3 fatty acids; coenzyme Q10

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Barden, A.; O’Callaghan, N.; Burke, V.; Mas, E.; Beilin, L.J.; Fenech, M.; Irish, A.B.; Watts, G.F.; Puddey, I.B.; Huang, R.-C.; Mori, T.A. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. Nutrients 2016, 8, 175.

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