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Nutrients 2016, 8(2), 38; doi:10.3390/nu8020038

Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver

1
Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil
2
Department of Cell Biology, Biological Sciences Institute, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil
*
Author to whom correspondence should be addressed.
Received: 25 November 2015 / Revised: 26 November 2015 / Accepted: 14 December 2015 / Published: 17 February 2016
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Abstract

This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) diet, for 30 days. Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine. Tucum-do-cerrado consumption reduced spleen lipid and protein oxidation; mRNA levels of hepatic Hamp and Ftl, and increased serum antioxidant capacity and hepatic mRNA levels of Bmp6, Hmox1, Nqo1, and Nrf2. TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues. These results suggest that tucum-do-cerrado protects tissues against oxidative damage, by reducing iron availability in liver and consequently inhibiting liver Hamp expression. View Full-Text
Keywords: oxidative stress; tucum-do-cerrado (Bactris setosa Mart.); Hamp; Nfr2 oxidative stress; tucum-do-cerrado (Bactris setosa Mart.); Hamp; Nfr2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fustinoni-Reis, A.M.; Arruda, S.F.; Dourado, L.P.S.; da Cunha, M.S.B.; Siqueira, E.M.A. Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver. Nutrients 2016, 8, 38.

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