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Nutrients 2016, 8(12), 812; doi:10.3390/nu8120812

Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos

Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Louisville, KY 40201, USA
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Received: 3 November 2016 / Revised: 9 December 2016 / Accepted: 13 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Vitamin A Update 2016)
View Full-Text   |   Download PDF [2094 KB, uploaded 15 December 2016]   |  

Abstract

Embryonic development is orchestrated by a small number of signaling pathways, one of which is the retinoic acid (RA) signaling pathway. Vitamin A is essential for vertebrate embryonic development because it is the molecular precursor of the essential signaling molecule RA. The level and distribution of RA signaling within a developing embryo must be tightly regulated; too much, or too little, or abnormal distribution, all disrupt embryonic development. Precise regulation of RA signaling during embryogenesis is achieved by proteins involved in vitamin A metabolism, retinoid transport, nuclear signaling, and RA catabolism. The reversible first step in conversion of the precursor vitamin A to the active retinoid RA is mediated by retinol dehydrogenase 10 (RDH10) and dehydrogenase/reductase (SDR family) member 3 (DHRS3), two related membrane-bound proteins that functionally activate each other to mediate the interconversion of retinol and retinal. Alcohol dehydrogenase (ADH) enzymes do not contribute to RA production under normal conditions during embryogenesis. Genes involved in vitamin A metabolism and RA catabolism are expressed in tissue-specific patterns and are subject to feedback regulation. Mutations in genes encoding these proteins disrupt morphogenesis of many systems in a developing embryo. Together these observations demonstrate the importance of vitamin A metabolism in regulating RA signaling during embryonic development in vertebrates. View Full-Text
Keywords: retinoic acid; review; metabolism; signaling; embryo; development; Rdh10; Dhrs3; retinoid; vitamin A retinoic acid; review; metabolism; signaling; embryo; development; Rdh10; Dhrs3; retinoid; vitamin A
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Metzler, M.A.; Sandell, L.L. Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos. Nutrients 2016, 8, 812.

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