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Nutrients 2016, 8(12), 797; doi:10.3390/nu8120797

A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women

1
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
2
Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
3
Biostatistics Team, Samsung Biomedical Research Institute, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
4
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
5
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
Current Address: Department of Statistics, Pukyong National University, Busan 48513, Korea.
Current Address: Division of Endocrinology and Metabolism, Department of Medicine, Gyeongsang National University School of Medicine, Jinju 52727, Korea.
§
Current Address: Institute of Health Sciences, Jinju 52727, Korea.
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Current Address: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul 04401, Korea.
*
Authors to whom correspondence should be addressed.
Received: 12 September 2016 / Revised: 15 November 2016 / Accepted: 2 December 2016 / Published: 8 December 2016
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Abstract

This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities. The median (range) MMA level was 0.142 (0.063–0.446) µmol/L and homocysteine level was 10.6 (4.4–38.0) µmol/L in pregnant women. MMA levels were significantly higher in the third trimester than during other trimesters (p < 0.05), while homocysteine levels were not. No significant association was observed between MMA or homocysteine levels and any of the maternal or neonatal outcomes examined. Future studies are needed to assess the associations among maternal serum concentrations of MMA and homocysteine, and maternal and neonatal outcomes. View Full-Text
Keywords: methylmalonic acid; homocysteine; vitamin B12; pregnancy methylmalonic acid; homocysteine; vitamin B12; pregnancy
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MDPI and ACS Style

Choi, R.; Choi, S.; Lim, Y.; Cho, Y.Y.; Kim, H.J.; Kim, S.W.; Chung, J.H.; Oh, S.-Y.; Lee, S.-Y. A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women. Nutrients 2016, 8, 797.

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