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Nutrients 2016, 8(12), 772; doi:10.3390/nu8120772

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

1
Nofer Institute of Occupational Medicine, Department of Toxicology and Carcinogenesis, Sw. Teresy 8 Street, 91-348 Lodz, Poland
2
Nofer Institute of Occupational Medicine, Department of Biological and Environmental Monitoring, Sw. Teresy 8 Street, 91-348 Lodz, Poland
3
European Institute of Oncology, Division of Epidemiology and Biostatistics, via Ripamonti 435, Milan 20139, Italy
4
The Medical University of Bialystok, Department of Bromatoloy, A. Mickiewicza 2D Street, 15-222 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Received: 10 October 2016 / Revised: 15 November 2016 / Accepted: 24 November 2016 / Published: 13 December 2016
(This article belongs to the Special Issue Nutrition and Diet Factors in Type 2 Diabetes)
View Full-Text   |   Download PDF [260 KB, uploaded 13 December 2016]

Abstract

The aim of the study was to evaluate the effect of selenium supplementation on the expression of genes associated with glucose metabolism in humans, in order to explain the unclear relationship between selenium and the risk of diabetes. For gene expression analysis we used archival samples of cDNA from 76 non-diabetic subjects supplemented with selenium in the previous study. The supplementation period was six weeks and the daily dose of selenium was 200 µg (as selenium yeast). Blood for mRNA isolation was collected at four time points: before supplementation, after two and four weeks of supplementation, and after four weeks of washout. The analysis included 15 genes encoding selected proteins involved in insulin signaling and glucose metabolism. In addition, HbA1c and fasting plasma glucose were measured at three and four time points, respectively. Selenium supplementation was associated with a significantly decreased level of HbA1c but not fasting plasma glucose (FPG) and significant down-regulation of seven genes: INSR, ADIPOR1, LDHA, PDHA, PDHB, MYC, and HIF1AN. These results suggest that selenium may affect glycemic control at different levels of regulation, linked to insulin signaling, glycolysis, and pyruvate metabolism. Further research is needed to investigate mechanisms of such transcriptional regulation and its potential implication in direct metabolic effects. View Full-Text
Keywords: selenium; gene expression; insulin signaling; glucose metabolism; glycolysis; pyruvate metabolism; energy metabolism; glycated hemoglobin; fasting plasma glucose selenium; gene expression; insulin signaling; glucose metabolism; glycolysis; pyruvate metabolism; energy metabolism; glycated hemoglobin; fasting plasma glucose
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jablonska, E.; Reszka, E.; Gromadzinska, J.; Wieczorek, E.; Krol, M.B.; Raimondi, S.; Socha, K.; Borawska, M.H.; Wasowicz, W. The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism. Nutrients 2016, 8, 772.

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