Low-Density Lipoprotein Receptor Contributes to β-Carotene Uptake in the Maternal Liver
AbstractVitamin A regulates many essential mammalian biological processes, including embryonic development. β-carotene is the main source of vitamin A in the human diet. Once ingested, it is packaged into lipoproteins, predominantly low-density lipoproteins (LDL), and transported to different sites within the body, including the liver and developing tissues, where it can either be stored or metabolized to retinoids (vitamin A and its derivatives). The molecular mechanisms of β-carotene uptake by the liver or developing tissues remain elusive. Here, we investigated the role of the LDL receptor (LDLr) in β-carotene uptake by maternal liver, placenta and embryo. We administered a single dose of β-carotene to Ldlr+/− and Ldlr−/− pregnant mice via intraperitoneal injection at mid-gestation and monitored the changes in β-carotene content among maternal lipoproteins and the liver, as well as the accumulation of β-carotene in the placental–fetal unit. We showed an abnormal β-carotene distribution among serum lipoproteins and reduced hepatic β-carotene uptake in Ldlr−/− dams. These data strongly imply that LDLr significantly contributes to β-carotene uptake in the adult mouse liver. In contrast, LDLr does not seem to mediate acquisition of β-carotene by the placental–fetal unit. View Full-Text
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Shete, V.; Costabile, B.K.; Kim, Y.-K.; Quadro, L. Low-Density Lipoprotein Receptor Contributes to β-Carotene Uptake in the Maternal Liver. Nutrients 2016, 8, 765.
Shete V, Costabile BK, Kim Y-K, Quadro L. Low-Density Lipoprotein Receptor Contributes to β-Carotene Uptake in the Maternal Liver. Nutrients. 2016; 8(12):765.Chicago/Turabian Style
Shete, Varsha; Costabile, Brianna K.; Kim, Youn-Kyung; Quadro, Loredana. 2016. "Low-Density Lipoprotein Receptor Contributes to β-Carotene Uptake in the Maternal Liver." Nutrients 8, no. 12: 765.
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