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Nutrients 2016, 8(11), 736; doi:10.3390/nu8110736

Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults

1
QPS-Miami Research Associates, 6141 Sunset Dr., Suite 301, South Miami, FL 33143, USA
2
Miller School of Medicine, University of Miami, Miami, FL 33136, USA
3
Nutrition 21 LLC, JDS Therapeutics LLC, 1 Manhattanville Rd., Purchase, NY 10577, USA
*
Author to whom correspondence should be addressed.
Received: 22 September 2016 / Revised: 3 November 2016 / Accepted: 11 November 2016 / Published: 18 November 2016
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Abstract

Inositol-stabilized arginine silicate (ASI; Nitrosigine®) has been validated to increase levels of arginine, silicon and nitric oxide production. To evaluate potential enhancement of mental focus and clarity, ASI (1500 mg/day) was tested in two double-blind placebo-controlled crossover (DBPC-X) studies using the Trail Making Test (TMT, Parts A and B). In the two studies, healthy males took ASI for 14 and 3 days, respectively. In the first study, after 14 days of dosing, TMT B time decreased significantly from baseline (28% improvement, p = 0.045). In the second study evaluating shorter-term effects, TMT B time decreased significantly compared to placebo (33% improvement, p = 0.024) in a 10-min period. After 3 days of dosing, TMT B time significantly decreased from baseline scores (35% improvement, p < 0.001). These findings show that ASI significantly improved the ability to perform complex cognitive tests requiring mental flexibility, processing speed and executive functioning. View Full-Text
Keywords: l-arginine; silicate; nitric oxide; cognitive function; mental flexibility l-arginine; silicate; nitric oxide; cognitive function; mental flexibility
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MDPI and ACS Style

Kalman, D.; Harvey, P.D.; Perez Ojalvo, S.; Komorowski, J. Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults. Nutrients 2016, 8, 736.

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