Next Article in Journal
The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis
Next Article in Special Issue
The Spectrum of Differences between Childhood and Adulthood Celiac Disease
Previous Article in Journal
Dietary Sources of Vitamin B-12 and Their Association with Vitamin B-12 Status Markers in Healthy Older Adults in the B-PROOF Study
Previous Article in Special Issue
Seronegative Celiac Disease and Immunoglobulin Deficiency: Where to Look in the Submerged Iceberg?
Article Menu

Export Article

Open AccessArticle
Nutrients 2015, 7(9), 7798-7805; doi:10.3390/nu7095368

Cutaneous Manifestations of Non-Celiac Gluten Sensitivity: Clinical Histological and Immunopathological Features

1
Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Viale Michelangiolo 41, Florence 50125, Italy
2
Director SOS Skin Immunopathology and Rare Dermatological Diseases Unit, 1st Dermatological Clinic ASF-Piero Palagi, Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence, Viale Michelangiolo 41, Florence 50125, Italy
*
Author to whom correspondence should be addressed.
Received: 14 June 2015 / Revised: 3 September 2015 / Accepted: 8 September 2015 / Published: 15 September 2015
(This article belongs to the Special Issue Gluten Related Disorders: People Shall not Live on Bread Alone)
View Full-Text   |   Download PDF [91 KB, uploaded 15 September 2015]   |  

Abstract

Background: The dermatological manifestations associated with intestinal diseases are becoming more frequent, especially now when new clinical entities, such as Non-Celiac Gluten Sensitivity (NCGS), are identified. The existence of this new entity is still debated. However, many patients with diagnosed NCGS that present intestinal manifestations have skin lesions that need appropriate characterization. Methods: We involved 17 patients affected by NCGS with non-specific cutaneous manifestations who got much better after a gluten free diet. For a histopathological and immunopathological evaluation, two skin samples from each patient and their clinical data were collected. Results: The median age of the 17 enrolled patients affected by NCGS was 36 years and 76% of them were females. On the extensor surfaces of upper and lower limbs in particular, they all presented very itchy dermatological manifestations morphologically similar to eczema, psoriasis or dermatitis herpetiformis. This similarity was also confirmed histologically, but the immunopathological analysis showed the prevalence of deposits of C3 along the dermo-epidermal junction with a microgranular/granular pattern (82%). Conclusions: The exact characterization of new clinical entities such as Cutaneous Gluten Sensitivity and NCGS is an important objective both for diagnostic and therapeutic purposes, since these are patients who actually benefit from a GFD (Gluten Free Diet) and who do not adopt it only for fashion. View Full-Text
Keywords: non-celiac gluten sensitivity; cutaneous gluten sensitivity; skin manifestations; direct immunofluorescence non-celiac gluten sensitivity; cutaneous gluten sensitivity; skin manifestations; direct immunofluorescence
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bonciolini, V.; Bianchi, B.; Del Bianco, E.; Verdelli, A.; Caproni, M. Cutaneous Manifestations of Non-Celiac Gluten Sensitivity: Clinical Histological and Immunopathological Features. Nutrients 2015, 7, 7798-7805.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top