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Nutrients 2015, 7(8), 6313-6329; doi:10.3390/nu7085292

Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet

1
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, 123 Mittraparp Highway, Muang District, Khon Kaen 40002, Thailand
2
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3
Department of Food technology, Faculty of Technology, Khon Kaen University, Khon Kaen 40002, Thailand
*
Author to whom correspondence should be addressed.
Received: 9 June 2015 / Revised: 9 June 2015 / Accepted: 27 July 2015 / Published: 3 August 2015
(This article belongs to the Special Issue Natural Products for Human Health)
View Full-Text   |   Download PDF [1315 KB, uploaded 3 August 2015]   |  

Abstract

A high carbohydrate-high fat (HCHF) diet causes insulin resistance (IR) and metabolic syndrome (MS). Rice bran has been demonstrated to have anti-dyslipidemic and anti-atherogenic properties in an obese mouse model. In the present study, we investigated the beneficial effects of rice bran protein hydrolysates (RBP) in HCHF-induced MS rats. After 12 weeks on this diet, the HCHF-fed group was divided into four subgroups, which were orally administered RBP 100 or 500 mg/kg, pioglitazone 10 mg/kg, or tap water for a further 6 weeks. Compared with normal diet control group, the MS rats had elevated levels of blood glucose, lipid, insulin, and HOMA-IR. Treatment with RBP significantly alleviated all those changes and restored insulin sensitivity. Additionally, RBP treatment increased adiponectin and suppressed leptin levels. Expression of Ppar-γ mRNA in adipose tissues was significantly increased whereas expression of lipogenic genes Srebf1 and Fasn was significantly decreased. Levels of mRNA of proinflammatory cytokines, Il-6, Tnf-α, Nos-2 and Mcp-1 were significantly decreased. In conclusion, the present findings support the consumption of RBP as a functional food to improve insulin resistance and to prevent the development of metabolic syndrome. View Full-Text
Keywords: metabolic syndrome; insulin resistance; rice bran protein hydrolysates (RBP); inflammatory cytokines metabolic syndrome; insulin resistance; rice bran protein hydrolysates (RBP); inflammatory cytokines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Boonloh, K.; Kukongviriyapan, V.; Kongyingyoes, B.; Kukongviriyapan, U.; Thawornchinsombut, S.; Pannangpetch, P. Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet. Nutrients 2015, 7, 6313-6329.

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