Next Article in Journal
What Is the Most Effective Way of Increasing the Bioavailability of Dietary Long Chain Omega-3 Fatty Acids—Daily vs. Weekly Administration of Fish Oil?
Previous Article in Journal
Inhibition of Pancreatic Lipase and Triacylglycerol Intestinal Absorption by a Pinhão Coat (Araucaria angustifolia) Extract Rich in Condensed Tannin
Article Menu

Export Article

Open AccessArticle
Nutrients 2015, 7(7), 5615-5627; doi:10.3390/nu7075243

Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition

1
Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 581 85, Sweden
2
Department of Biosciences and Nutrition, Karolinska Institute, NOVUM, Huddinge SE 141 83, Sweden
*
Author to whom correspondence should be addressed.
Received: 21 May 2015 / Revised: 24 June 2015 / Accepted: 2 July 2015 / Published: 10 July 2015
View Full-Text   |   Download PDF [298 KB, uploaded 10 July 2015]   |  

Abstract

Intrauterine factors influence infant size and body composition but the mechanisms involved are to a large extent unknown. We studied relationships between the body composition of pregnant women and variables related to their glucose homeostasis, i.e., glucose, HOMA-IR (homeostasis model assessment-insulin resistance), hemoglobin A1c and IGFBP-1 (insulin-like growth factor binding protein-1), and related these variables to the body composition of their infants. Body composition of 209 women in gestational week 32 and of their healthy, singleton and full-term one-week-old infants was measured using air displacement plethysmography. Glucose homeostasis variables were assessed in gestational week 32. HOMA-IR was positively related to fat mass index and fat mass (r2 = 0.32, p < 0.001) of the women. Maternal glucose and HOMA-IR values were positively (p ≤ 0.006) associated, while IGFBP-1was negatively (p = 0.001) associated, with infant fat mass. HOMA-IR was positively associated with fat mass of daughters (p < 0.001), but not of sons (p = 0.65) (Sex-interaction: p = 0.042). In conclusion, glucose homeostasis variables of pregnant women are related to their own body composition and to that of their infants. The results suggest that a previously identified relationship between fat mass of mothers and daughters is mediated by maternal insulin resistance. View Full-Text
Keywords: body composition; infant; insulin resistance; pregnancy; sex difference body composition; infant; insulin resistance; pregnancy; sex difference
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Henriksson, P.; Löf, M.; Forsum, E. Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition. Nutrients 2015, 7, 5615-5627.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top