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Nutrients 2015, 7(7), 5601-5614; doi:10.3390/nu7075242

Inhibition of Pancreatic Lipase and Triacylglycerol Intestinal Absorption by a Pinhão Coat (Araucaria angustifolia) Extract Rich in Condensed Tannin

1
Department of Biochemistry, State University of Maringá, Maringá 87020900, Brazil
2
Instituto Federal do Paraná, Jacarezinho 86400000, Brazil
3
Department of Nutrition, Federal University of the South Border, Realeza 85770000, Brazil
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 April 2015 / Revised: 27 May 2015 / Accepted: 30 June 2015 / Published: 9 July 2015
(This article belongs to the Special Issue Natural Products for Human Health)
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Abstract

The purpose of the present work was to characterize the possible inhibition of pancreatic lipase by a tannin-rich extract obtained from the pinhão (Araucaria angustifolia seed) coat, based on the previous observation that this preparation inhibits α-amylases. Kinetic measurements of pancreatic lipase revealed that the pinhão coat tannin is an effective inhibitor. Inhibition was of the parabolic non-competitive type. The inhibition constants, \({\overline{K}}_{i1} \) and \({\overline{K}}_{i2} \), were equal to 332.7 ± 146.1 µg/mL and 321.2 \(\pm\) 93.0 µg/mL, respectively, corresponding roughly to the inhibitor concentration producing 50. View Full-Text
Keywords: tannins; lipase; enzyme; obesity tannins; lipase; enzyme; obesity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Oliveira, R.F.; Gonçalves, G.A.; Inácio, F.D.; Koehnlein, E.A.; de Souza, C.G.M.; Bracht, A.; Peralta, R.M. Inhibition of Pancreatic Lipase and Triacylglycerol Intestinal Absorption by a Pinhão Coat (Araucaria angustifolia) Extract Rich in Condensed Tannin. Nutrients 2015, 7, 5601-5614.

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