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Nutrients 2015, 7(7), 5542-5555; doi:10.3390/nu7075237

Acute and Chronic Effects of Dietary Lactose in Adult Rats Are not Explained by Residual Intestinal Lactase Activity

Danone Nutricia Research, PO Box 80141, 3508 TC Utrecht, The Netherlands
Author to whom correspondence should be addressed.
Received: 5 June 2015 / Revised: 16 June 2015 / Accepted: 30 June 2015 / Published: 8 July 2015
(This article belongs to the Special Issue Lactose Intolerance: Biology, Genetics and Dietary Management)
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Neonatal rats have a high intestinal lactase activity, which declines around weaning. Yet, the effects of lactose-containing products are often studied in adult animals. This report is on the residual, post-weaning lactase activity and on the short- and long-term effects of lactose exposure in adult rats. Acutely, the postprandial plasma response to increasing doses of lactose was studied, and chronically, the effects of a 30% lactose diet fed from postnatal (PN) Day 15 onwards were evaluated. Intestinal lactase activity, as assessed both in vivo and in vitro, was compared between both test methods and diet groups (lactose vs. control). A 50%–75% decreased digestive capability towards lactose was observed from weaning into adulthood. Instillation of lactose in adult rats showed disproportionally low increases in plasma glucose levels and did not elicit an insulin response. However, gavages comprising maltodextrin gave rise to significant plasma glucose and insulin responses, indicative of a bias of the adult GI tract to digest glucose polymers. Despite the residual intestinal lactase activity shown, a 30% lactose diet was poorly digested by adult rats: the lactose diet rendered the animals less heavy and virtually devoid of body fat, whereas their cecum tripled in size, suggesting an increased bacterial fermentation. The observed acute and chronic effects of lactose exposure in adult rats cannot be explained by the residual intestinal lactase activity assessed. View Full-Text
Keywords: digestion; lactose; lactase; galactosyl xylose; infant milk formula; rats digestion; lactose; lactase; galactosyl xylose; infant milk formula; rats

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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de Heijning, B.J.M.; Kegler, D.; Schipper, L.; Voogd, E.; Oosting, A.; Beek, E.M. Acute and Chronic Effects of Dietary Lactose in Adult Rats Are not Explained by Residual Intestinal Lactase Activity. Nutrients 2015, 7, 5542-5555.

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