A Dietary Pattern Derived by Reduced Rank Regression is Associated with Type 2 Diabetes in An Urban Ghanaian Population
AbstractReduced rank regression (RRR) is an innovative technique to establish dietary patterns related to biochemical risk factors for type 2 diabetes, but has not been applied in sub-Saharan Africa. In a hospital-based case-control study for type 2 diabetes in Kumasi (diabetes cases, 538; controls, 668) dietary intake was assessed by a specific food frequency questionnaire. After random split of our study population, we derived a dietary pattern in the training set using RRR with adiponectin, HDL-cholesterol and triglycerides as responses and 35 food items as predictors. This pattern score was applied to the validation set, and its association with type 2 diabetes was examined by logistic regression. The dietary pattern was characterized by a high consumption of plantain, cassava, and garden egg, and a low intake of rice, juice, vegetable oil, eggs, chocolate drink, sweets, and red meat; the score correlated positively with serum triglycerides and negatively with adiponectin. The multivariate-adjusted odds ratio of type 2 diabetes for the highest quintile compared to the lowest was 4.43 (95% confidence interval: 1.87–10.50, p for trend < 0.001). The identified dietary pattern increases the odds of type 2 diabetes in urban Ghanaians, which is mainly attributed to increased serum triglycerides. View Full-Text
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Frank, L.K.; Jannasch, F.; Kröger, J.; Bedu-Addo, G.; Mockenhaupt, F.P.; Schulze, M.B.; Danquah, I. A Dietary Pattern Derived by Reduced Rank Regression is Associated with Type 2 Diabetes in An Urban Ghanaian Population. Nutrients 2015, 7, 5497-5514.
Frank LK, Jannasch F, Kröger J, Bedu-Addo G, Mockenhaupt FP, Schulze MB, Danquah I. A Dietary Pattern Derived by Reduced Rank Regression is Associated with Type 2 Diabetes in An Urban Ghanaian Population. Nutrients. 2015; 7(7):5497-5514.Chicago/Turabian Style
Frank, Laura K.; Jannasch, Franziska; Kröger, Janine; Bedu-Addo, George; Mockenhaupt, Frank P.; Schulze, Matthias B.; Danquah, Ina. 2015. "A Dietary Pattern Derived by Reduced Rank Regression is Associated with Type 2 Diabetes in An Urban Ghanaian Population." Nutrients 7, no. 7: 5497-5514.