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Nutrients 2015, 7(7), 5469-5483; doi:10.3390/nu7075232

Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice

1
College of Pharmacy & Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-951, Korea
2
Department of Biomedical Laboratory Science, College of Natural Science, Daejeon University, Daejeon 300-716, Korea
3
Department of Physiology, College of Korean Medicine, Daejeon University, Daejeon 300-716, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 April 2015 / Revised: 21 May 2015 / Accepted: 25 June 2015 / Published: 7 July 2015
(This article belongs to the Special Issue Natural Products for Human Health)
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Abstract

Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycosylation and esterification to obtained ziyuglycoside II methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic activity than the original compound (ZG01) through decreasing blood glucose, glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2 diabetes (db/db mice). We further found that ZG02-ME treatment effectively ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic hormones, in db/db mice. In addition, we showed that elevated basal blood lipid levels were decreased by ZG02-ME treatment in db/db mice. Furthermore, treatment of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver lipid peroxidation in db/db mice. These results demonstrated that compared to ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and has hepato-renal protective activities in type 2 diabetes. View Full-Text
Keywords: ziyuglycoside; Sanguisorba officinalis; diabetes; diabetic hepatopathy; diabetic nephropathy ziyuglycoside; Sanguisorba officinalis; diabetes; diabetic hepatopathy; diabetic nephropathy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Son, D.J.; Hwang, S.Y.; Kim, M.-H.; Park, U.K.; Kim, B.S. Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice. Nutrients 2015, 7, 5469-5483.

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