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Nutrients 2015, 7(7), 5156-5176; doi:10.3390/nu7075156

Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors

1
Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA
2
Rocky Mountain Cancer Centers, Denver, CO 80220, USA
3
Colorado Biostatistics Consortium, University of Colorado, Denver, CO 80045, USA
4
Department of Internal Medicine, University of Vermont, Burlington, VT 05405, USA
5
Department of Chronic Disease Epidemiology, Yale University, New Haven, CT 06520, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 27 April 2015 / Revised: 10 June 2015 / Accepted: 18 June 2015 / Published: 26 June 2015
(This article belongs to the Special Issue Dietary Pattern and Health)
View Full-Text   |   Download PDF [984 KB, uploaded 26 June 2015]   |  

Abstract

Women who are obese at the time of breast cancer diagnosis have higher overall mortality than normal weight women and some evidence implicates adiponectin and leptin as contributing to prognostic disadvantage. While intentional weight loss is thought to improve prognosis, its impact on these adipokines is unclear. This study compared the pattern of change in plasma leptin and adiponectin in overweight-to-obese post-menopausal breast cancer survivors during weight loss. Given the controversies about what dietary pattern is most appropriate for breast cancer control and regulation of adipokine metabolism, the effect of a low fat versus a low carbohydrate pattern was evaluated using a non-randomized, controlled study design. Anthropometric data and fasted plasma were obtained monthly during the six-month weight loss intervention. While leptin was associated with fat mass, adiponectin was not, and the lack of correlation between leptin and adiponectin concentrations throughout weight loss implies independent mechanisms of regulation. The temporal pattern of change in leptin but not adiponectin was affected by magnitude of weight loss. Dietary pattern was without effect on either adipokine. Mechanisms not directly related to dietary pattern, weight loss, or fat mass appear to play dominant roles in the regulation of circulating levels of these adipokines. View Full-Text
Keywords: adiponectin; body composition; breast cancer survivors; dietary pattern; leptin; weight loss adiponectin; body composition; breast cancer survivors; dietary pattern; leptin; weight loss
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Thompson, H.J.; Sedlacek, S.M.; Wolfe, P.; Paul, D.; Lakoski, S.G.; Playdon, M.C.; McGinley, J.N.; Matthews, S.B. Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors. Nutrients 2015, 7, 5156-5176.

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