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Nutrients 2015, 7(5), 3138-3153; doi:10.3390/nu7053138

Consumption of a Polyphenol-Rich Grape-Wine Extract Lowers Ambulatory Blood Pressure in Mildly Hypertensive Subjects

Unilever Research & Development Vlaardingen, Olivier van Noortlaan 120, Vlaardingen 3133 AT, The Netherlands
Academic Medical Center Amsterdam, Department of Vascular Medicine, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
Current address: Menzis, Lawickse Allee 130, Wageningen 6709 DZ, The Netherlands.
Current address: Imagelabonline & Cardiovascular, Erichem 4117 GV, The Netherlands.
Current address: Red Pharm, Cold Meece, Swynnerton, Staffordshire ST15 0SP, UK.
Author to whom correspondence should be addressed.
Received: 3 February 2015 / Revised: 10 April 2015 / Accepted: 22 April 2015 / Published: 30 April 2015
(This article belongs to the Special Issue Nutrition and CVD)
View Full-Text   |   Download PDF [160 KB, uploaded 30 April 2015]   |  


Polyphenols in grape and wine have been suggested to contribute to the cardiovascular health benefits of the Mediterranean lifestyle. The reported effects of grape products on blood pressure (BP) remain, however, equivocal. In a double-blind placebo controlled crossover study, the effect of two grape extracts on BP and vascular function was assessed in 60 untreated, mildly hypertensive subjects after four weeks intervention. Both extracts (grape-red wine and grape alone) had high concentrations of anthocyanins and flavonols, but the grape alone was relatively poor in catechins and procyanidins. Parameters measured included ambulatory and office BP, flow-mediated vasodilation, arterial distensibility, platelet function and plasma lipoproteins. Results showed that 24-hour ambulatory systolic/diastolic BPs were significantly lower in the grape-wine extract intervention (135.9 ± 1.3/84.7 ± 0.8 mmHg; mean ± SEM) compared to placebo (138.9 ± 1.3/86.6 ± 1.2 mmHg), predominantly during daytime. Plasma concentrations of the vasoconstrictor endothelin-1 decreased by 10%, but other measures of vascular function were not affected. Grape juice extract alone had no effect on BP or any measures of vascular function. Polyphenol-rich food products, and may be specifically catechins and procyanidins, may thus help sustain a healthy BP and contribute to the healthy Mediterranean lifestyle. View Full-Text
Keywords: red wine; grape; polyphenols; blood pressure; vascular function; catechins; procyanidins red wine; grape; polyphenols; blood pressure; vascular function; catechins; procyanidins

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Draijer, R.; de Graaf, Y.; Slettenaar, M.; de Groot, E.; Wright, C.I. Consumption of a Polyphenol-Rich Grape-Wine Extract Lowers Ambulatory Blood Pressure in Mildly Hypertensive Subjects. Nutrients 2015, 7, 3138-3153.

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